PDE5A wt Allele

Known as: Phosphodiesterase 5A, cGMP-Specific wt Allele, Phosphodiesterase Isozyme 5 Gene, CGB-PDE 
Human PDE5A wild-type allele is located in the vicinity of 4q27 and is approximately 135 kb in length. This allele, which encodes cGMP-specific 3',5… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND In heart failure (HF), a defective nitric oxide signaling is involved in left ventricular (LV) diastolic abnormalities… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP catabolism, is increased in human… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Sildenafil was recently approved for the treatment of pulmonary arterial hypertension. The beneficial effects of… (More)
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Highly Cited
2007
Highly Cited
2007
Benign prostate hyperplasia is the most common disease in the aging male, often comorbid with erectile dysfunction… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Heart failure (HF) is frequently associated with dysregulation of nitric oxide-mediated pulmonary vascular tone… (More)
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Highly Cited
2004
Highly Cited
2004
By real-time RT-PCR and Western blot analysis, we found that phosphodiesterase type 5 (PDE5) mRNA and protein abundance was… (More)
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Review
2003
Review
2003
Cyclic GMP (cGMP) made in response to atrial natriuretic peptide (ANP) or nitric oxide (NO) is an important regulator of short… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Phosphodiesterase type 5 (PDE5) is a novel therapeutic target for the treatment of pulmonary hypertension. This study… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE We studied the effects of sildenafil, a phosphodiesterase 5 inhibitor, on coronary and peripheral vascular function… (More)
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Highly Cited
2000
Highly Cited
2000
In addition to its cGMP-selective catalytic site, cGMP-binding cGMP-specific phosphodiesterase (PDE5) contains two allosteric… (More)
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