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PDE5A wt Allele

Known as: Phosphodiesterase 5A, cGMP-Specific wt Allele, Phosphodiesterase Isozyme 5 Gene, CGB-PDE 
Human PDE5A wild-type allele is located in the vicinity of 4q27 and is approximately 135 kb in length. This allele, which encodes cGMP-specific 3',5… 
National Institutes of Health

Related topics

Related topics

3 relations
HydrolysisPDE5A protein, humanSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis
BackgroundPrevious meta-analyses of treatments for pulmonary arterial hypertension (PAH) have not shown mortality benefit from… 
Highly Cited
2010
Highly Cited
2010
Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression
We explored the antidepressant-like properties of two phosphodiesterase type 5 (PDE5) inhibitors in a genetic animal model of… 
Highly Cited
2008
Highly Cited
2008
Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions
It is generally accepted that nitric oxide (NO) donors, such as sodium nitroprusside (SNP), or phosphodiesterase 5 (PDE5… 
2008
2008
Giving patients with erectile dysfunction the opportunity to try all three available phosphodiesterase type 5 inhibitors contributes to better long-term treatment compliance.
INTRODUCTION There are three phosphodiesterase type 5 (PDE5) inhibitors marketed, sildenafil, Vardenafil, and tadalafil for oral… 
Review
2005
Review
2005
Cardiac safety in clinical trials of phosphodiesterase 5 inhibitors.
Highly Cited
2003
Highly Cited
2003
Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery
Sildenafil (viagra) is a potent PDE5 inhibitor and thus a relaxant drug in corpus carvernosum smooth muscle. In the present work… 
Highly Cited
2002
Highly Cited
2002
Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase.
Highly Cited
2002
Highly Cited
2002
Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation.
Chronic hypoxia (CH) augments endothelium-derived nitric oxide (NO)-dependent pulmonary vasodilation; however, responses to… 
Highly Cited
2001
Highly Cited
2001
The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat
Highly Cited
1999
Highly Cited
1999
Expression of an Active, Monomeric Catalytic Domain of the cGMP-binding cGMP-specific Phosphodiesterase (PDE5)*
Phosphodiesterases (PDEs) comprise a superfamily of phosphohydrolases that degrade 3′,5′-cyclic nucleotides. All known mammalian… 
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