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To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to… Expand In Zoccarato et al. (Zoccarato et al. 2015), we provide extensive evidence that inhibition of PDE2 counteracts cardiac myocyte… Expand Phosphodiesterase 2 (PDE2) is an enzyme responsible for hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine… Expand The cGMP-stimulated PDE2A hydrolyzes both cyclic nucleotides, cGMP and cAMP. Three splice variants have been cloned from several… Expand Background The cyclic nucleotide second messengers cAMP and cGMP play key roles in mammalian signal transduction. Their… Expand Human cyclic GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE2A3) cDNAs were cloned from hippocampus and fetal brain… Expand