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Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.
Nitric oxide (NO) binds with high affinity to the heme of soluble guanylyl cyclase (sGC), resulting in accumulation of the second messenger cGMP in many biological systems.Expand
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Sensitizing soluble guanylyl cyclase to become a highly CO‐sensitive enzyme.
It took at least a decade to realize that the toxic gas NO is the physiological activator of soluble guanylyl cyclase (sGC), thereby acting as a signaling molecule in the nervous and cardiovascularExpand
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Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach.
The intracellular signalling molecule cGMP regulates a variety of physiological processes, and so the ability to monitor cGMP dynamics in living cells is highly desirable. Here, we report aExpand
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NO activation of guanylyl cyclase
Nitric oxide (NO)‐sensitive guanylyl‐cyclase (GC) is the most important receptor for the signaling molecule NO. Activation of the enzyme is brought about by binding of NO to the prosthetic hemeExpand
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Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase
The signaling molecule nitric oxide (NO), first described as endothelium-derived relaxing factor (EDRF), acts as physiological activator of NO-sensitive guanylyl cyclase (NO-GC) in theExpand
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Nitric oxide-sensitive guanylyl cyclase: structure and regulation
By the formation of the second messenger cGMP, NO-sensitive guanylyl cyclase (GC) plays a key role within the NO/cGMP signaling cascade which participates in vascular regulation andExpand
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The function of NO-sensitive guanylyl cyclase: what we can learn from genetic mouse models.
The signaling molecule nitric oxide (NO) acts as physiological activator of NO-sensitive guanylyl cyclase (NO-GC) in the cardiovascular, gastrointestinal and nervous systems. Two isoforms of NO-GCExpand
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Direct activation of PDE5 by cGMP
In platelets, the nitric oxide (NO)–induced cGMP response is indicative of a highly regulated interplay of cGMP formation and cGMP degradation. Recently, we showed that within the NO-induced cGMPExpand
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Guanylyl Cyclase/PSD-95 Interaction
The signaling molecule nitric oxide (NO) exerts most of its effects by the stimulation of the NO-sensitive guanylyl cyclase. Two isoforms of the NO receptor molecule exist: the ubiquitously occurringExpand
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Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system.
In the vascular system, the receptor for the signaling molecule NO, guanylyl cyclase (GC), mediates smooth muscle relaxation and inhibition of platelet aggregation by increasing intracellular cyclicExpand
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