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PD 184352

Known as: PD 184352/CI-1040, PD-184352, MEK Inhibitor CI-1040 
An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
UNLABELLED Recently, the rationale for combining targeted therapy with immunotherapy has come to light, but our understanding of… Expand
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Highly Cited
2010
Highly Cited
2010
Store-operated calcium entry (SOCE) is an important Ca2+ entry pathway that regulates many cell functions. Upon store depletion… Expand
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Highly Cited
2008
Highly Cited
2008
Abnormal intracellular signaling contributes to carcinogenesis and may represent novel therapeutic targets. mitogen/extracellular… Expand
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Review
2006
Review
2006
The extracellular signal‐regulated kinase (ERK) signaling pathway is a major determinant in the control of diverse cellular… Expand
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Highly Cited
2005
Highly Cited
2005
SummaryWe have previously demonstrated that oestrogen receptor α (ERα) modulates epidermal growth factor receptor (EGFR)/mitogen… Expand
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Highly Cited
2003
Highly Cited
2003
  • Yao Yao, Wei Li, +4 authors Diane M. Boucher
  • Proceedings of the National Academy of Sciences…
  • 2003
  • Corpus ID: 43040999
The extracellular signal-regulated kinase (ERK) is a component of the mitogen-activated protein kinase cascade. Exon 2 of erk2… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly… Expand
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2002
2002
Utilizing a genetic screen in the yeast Saccharomyces cerevisiae, we identified a novel autoactivation region in mammalian MEK1… Expand
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Highly Cited
2001
Highly Cited
2001
The mitogen-activated protein kinase (MAPK) pathway regulates growth and survival of many cell types, and its constitutive… Expand
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… Expand
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