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PD 184352

Known as: PD 184352/CI-1040, PD-184352, MEK Inhibitor CI-1040 
An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular… 
National Institutes of Health

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CI 1040NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation… 
2016
2016
Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.
In Fig. 3A, the image of mouse hepatocytes overexpressing p21 and treated with PD184352 (PD) and deoxycholic acid (DCA) was… 
2016
2016
Correction to: “Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment”
It has been pointed out to us that the control 0 min time point bands in Figure 2E were duplicated. The control lanes were… 
2014
2014
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells
Hepatocyte tumor cell lines lack the expression or induction properties of major cytochrome P450 (CYP) enzymes compared to… 
2012
2012
Abstract 4667: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1 anti-apoptotic function and bortezomib resistance in human multiple myeloma cells
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Mcl-1, a critical survival factor for human… 
2009
2009
ERK 5 Expression in Human Prostate Cancer Clinical Significance of Abnormal Extracellular Signal – Regulated Kinase 5 ( ERK 5 ) Expression in Human Prostate Cancer
The MEK5/ERK5 pathway has recently been implicated in prostate and breast carcinogenesis. Over-expression of MEK5 is associat ed… 
2007
2007
Year : 2003 Chronic mild hypoxia protects heart-derived H 9 c 2 cells against acute hypoxia / reoxygenation by regulating expression of the SUR 2 A subunit of the ATP-sensitive K + channel
Chronic exposure to lower oxygen tension may increase cellular resistance to different types of acute metabolic stress. Here, we… 
2007
2007
Influence of PD184352 on the Proliferation and Expression of ERK Protein of Squamous Cell Carcinoma Tca8113
Objective:To observe the influence of PD184352 on the proliferation and expression of ERK protein of squamous cell carcinoma… 
2002
2002
myeloma cells through an IL-6-independent mechanism inhibitors potently induces apoptosis in drug-sensitive and-resistant Combined treatment with the checkpoint abrogator UCN-01 and MEK 1
The effects of combined exposure to the checkpoint abrogator UCN-01 and pharmacologic MEK1/2 inhibitors were examined in human… 
2001
2001
ects of MAP kinase cascade inhibitors on the MKK 5 / ERK 5 pathway
Antibodies that recognise the active phosphorylated forms of mitogen-activated protein kinase (MAPK) kinase 5 (MKK5) and… 
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