PD 184352

Known as: PD 184352/CI-1040, PD-184352, MEK Inhibitor CI-1040 
An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
05101520002018

Papers overview

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Highly Cited
2007
Highly Cited
2007
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a… (More)
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Highly Cited
2006
Highly Cited
2006
The expression of mitogen-activated protein kinases (MAPK) in DBA/2-pcy/pcy (pcy) mice, a murine model of polycystic kidney… (More)
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Highly Cited
2005
Highly Cited
2005
We have previously demonstrated that oestrogen receptor α (ERα) modulates epidermal growth factor receptor (EGFR)/mitogen… (More)
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2004
2004
Recent evidence indicates that mutations in the gene encoding the WNK1 [with no K (lysine) protein kinase-1] results in an… (More)
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Highly Cited
2003
Highly Cited
2003
The extracellular signal-regulated kinase (ERK) is a component of the mitogen-activated protein kinase cascade. Exon 2 of erk2… (More)
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Highly Cited
2003
Highly Cited
2003
TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38alpha at Ser423, Thr431 and Ser438 in vitro. TAB1 became… (More)
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2002
2002
Utilizing a genetic screen in the yeast Saccharomyces cerevisiae, we identified a novel autoactivation region in mammalian MEK1… (More)
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Highly Cited
2001
Highly Cited
2001
The mitogen-activated protein kinase (MAPK) pathway regulates growth and survival of many cell types, and its constitutive… (More)
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Highly Cited
2001
Highly Cited
2001
Antibodies that recognise the active phosphorylated forms of mitogen-activated protein kinase (MAPK) kinase 5 (MKK5) and… (More)
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… (More)
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