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PD 184352

Known as: PD 184352/CI-1040, PD-184352, MEK Inhibitor CI-1040 
An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular… 
National Institutes of Health

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CI 1040NCIt Antineoplastic Agent Terminology

Papers overview

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Highly Cited
2008
Highly Cited
2008
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that… 
Highly Cited
2007
Highly Cited
2007
Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.
OBJECTIVE To evaluate the role of the MEK/ERK MAP kinase pathway in murine collagen-induced arthritis (CIA) using the selective… 
Highly Cited
2006
Highly Cited
2006
Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.
The expression of mitogen-activated protein kinases (MAPK) in DBA/2-pcy/pcy (pcy) mice, a murine model of polycystic kidney… 
Highly Cited
2003
Highly Cited
2003
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
The extracellular signal-regulated kinase (ERK) is a component of the mitogen-activated protein kinase cascade. Exon 2 of erk2… 
Review
2003
Review
2003
CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK).
Several key growth factors, cytokines, and proto-oncogenes transduce their growth- and differentiation-promoting signals through… 
Highly Cited
2003
Highly Cited
2003
Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos
Review
2003
Review
2003
Signal transduction--directed cancer treatments.
The pathogenic mechanisms giving rise to cancer frequently involve altered signal transduction pathways. Therefore therapeutic… 
Highly Cited
2002
Highly Cited
2002
Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl…
Interactions between the kinase inhibitor STI571 and pharmacological antagonists of the mitogen-activated protein/extracellular… 
Highly Cited
2001
Highly Cited
2001
Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia.
The mitogen-activated protein kinase (MAPK) pathway regulates growth and survival of many cell types, and its constitutive… 
Highly Cited
2001
Highly Cited
2001
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia…
Interactions between the checkpoint abrogator UCN-01 and several pharmacological inhibitors of the mitogen-activated protein… 
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