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CI 1040

Known as: CI-1040, CI1040 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Lung adenocarcinoma cells harboring epidermal growth factor receptor (EGFR) mutations are sensitive to EGFR tyrosine kinase… Expand
Highly Cited
2009
Highly Cited
2009
Objective—Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost 10% of the population over age 65… Expand
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Highly Cited
2008
Highly Cited
2008
A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been… Expand
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Highly Cited
2008
Highly Cited
2008
The epidermal growth factor receptor (EGFR) inhibitor erlotinib is approved for treatment of pancreatic cancer but the overall… Expand
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Highly Cited
2007
Highly Cited
2007
CONTEXT Targeting MAPK kinase (MEK) in the MAPK pathway is a potentially effective therapeutic strategy for thyroid cancer… Expand
Highly Cited
2005
Highly Cited
2005
PURPOSE This phase I study was undertaken to define the toxicity, pharmacokinetics, pharmacodynamics, maximum tolerated dose (MTD… Expand
Highly Cited
2005
Highly Cited
2005
PD184352/CI-1040 is a potent and selective MEK1/2 inhibitor that represents the first MEK-targeted agent to enter clinical trials… Expand
Highly Cited
2005
Highly Cited
2005
Taxol may contribute to intrinsic chemoresistance by activating the mitogen-activated protein kinase kinase (MEK)/extracellular… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE This multicenter, open-label, phase II study was undertaken to assess the antitumor activity and safety of the oral… Expand
Review
2003
Review
2003
Several key growth factors, cytokines, and proto-oncogenes transduce their growth- and differentiation-promoting signals through… Expand