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PD 118057

Known as: PD-118057, PD118057 
National Institutes of Health

Papers overview

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Review
2014
Review
2014
The human ether-à-go-go related gene (hERG) potassium channel is an obligatory anti-target for drug development on account of its… 
2014
2014
Agonists bind to sites on all four subunits to activate human ether-a-go-go–related gene 1 (hERG1) K+ channels. 
2013
2013
Background Treatment of LQT2 is inadequate. Many drugs which can pharmacologically rescue defective protein trafficking in LQT2… 
Highly Cited
2011
Highly Cited
2011
Background Congenital Long QT Syndromes (LQTS) are associated with prolonged ventricular repolarisation and sudden cardiac death… 
2011
2011
Human ether-à-go-go-related gene 1 (hERG1) channels conduct the rapid delayed rectifier K+ current, IKr, an important determinant… 
Review
2010
Review
2010
Human ether‐á‐go‐go related gene (hERG) potassium (K+) channels play a critical role in cardiac action potential repolarization… 
Highly Cited
2009
Highly Cited
2009
Human ether-a-go-go-related gene 1 (hERG1) K+ channels mediate repolarization of cardiac action potentials. Unintended block of… 
Highly Cited
2005
Highly Cited
2005
A variety of drugs has been reported to cause acquired long QT syndrome through inhibition of the IKr channel. Screening…