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PD 118057

Known as: PD-118057, PD118057 
 
National Institutes of Health

Papers overview

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2014
2014
Agonists bind to sites on all four subunits to activate human ether-a-go-go–related gene 1 (hERG1) K+ channels. 
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2013
2013
Background Treatment of LQT2 is inadequate. Many drugs which can pharmacologically rescue defective protein trafficking in LQT2… Expand
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Highly Cited
2011
Highly Cited
2011
Aims Congenital long QT syndromes (LQTSs) are associated with prolonged ventricular repolarization and sudden cardiac death… Expand
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2011
2011
Human ether-à-go-go-related gene 1 (hERG1) channels conduct the rapid delayed rectifier K+ current, IKr, an important determinant… Expand
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2011
2011
Background Congenital Long QT Syndromes (LQTS) are associated with prolonged ventricular repolarisation and sudden cardiac death… Expand
2010
2010
BACKGROUND Short QT (SQT) syndrome (SQT) 1 is an inherited sudden death syndrome often associated with atrial fibrillation (AF… Expand
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2009
2009
Human ether-a-go-go-related gene 1 (hERG1) K+ channels mediate repolarization of cardiac action potentials. Unintended block of… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Short QT syndrome (SQTS) is a primary electrical disease of the heart associated with a high risk of sudden cardiac… Expand
2007
2007
Previous studies have shown that murine portal vein myocytes express ether-à-go-go related genes (ERGs) and exhibit distinctive… Expand
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Highly Cited
2005
Highly Cited
2005
A variety of drugs has been reported to cause acquired long QT syndrome through inhibition of the IKr channel. Screening… Expand