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Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.
Timothy syndrome (TS) is a multisystem disorder that causes syncope and sudden death from cardiac arrhythmias. Prominent features include congenital heart disease, immune deficiency, intermittentExpand
Models of cardiac tissue electrophysiology: progress, challenges and open questions.
Models of cardiac tissue electrophysiology are an important component of the Cardiac Physiome Project, which is an international effort to build multi-scale mathematical models of the heart. Expand
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.
OBJECTIVE The outward current flowing through the two-pore domain acid-sensitive potassium channel TASK-1 (I(TASK)) and its inhibition via alpha1-adrenergic receptors was studied in rat ventricularExpand
De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero.
OBJECTIVE We describe a genetic basis for atrial fibrillation and short QT syndrome in utero. Heterologous expression of the mutant channel was used to define the physiological consequences of theExpand
Verification of cardiac tissue electrophysiology simulators using an N-version benchmark
This study provides the first cardiac tissue electrophysiology simulation benchmark to allow these codes to be verified. Expand
Heterogeneous three-dimensional anatomical and electrophysiological model of human atria
Investigating the mechanisms underlying the genesis and conduction of electrical excitation in the atria at physiological and pathological states is of great importance. To provide knowledgeExpand
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel
Although chloroquine remains an important therapeutic agent for treatment of malaria in many parts of the world, its safety margin is very narrow. Chloroquine inhibits the cardiac inward rectifier K+Expand
Cardiac cell modelling: observations from the heart of the cardiac physiome project.
We review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. Expand
Computational Cardiology: Modeling Of Anatomy, Electrophysiology, And Mechanics (LECTURE NOTES IN COMPUTER SCIENCE)
1. Introduction.- 2. Mathematical and Numerical Foundation.- 3. Theory of Electric Fields.- 4. Continuum Mechanics. Expand
Electrophysiological Modeling of Fibroblasts and their Interaction with Myocytes
Experimental studies have shown that cardiac fibroblasts are electrically inexcitable, but can contribute to electrophysiology of myocardium in various manners. The aim of this computational studyExpand