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PCI 34051

Known as: PCI-34051, PCI34051 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Hydroxamic AcidsIndoles

Narrower (1)

PCI-34058

Papers overview

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2018
2018
Abstract 5801: Unexpected selectivity of histone deacetylase inhibitors in live MDA-MD-231 triple-negative breast cancer cells
While inhibition of histone deacetylases (HDAC) is a promising strategy for the treatment of cancer, HDACs do play essential… 
2015
2015
Abstract 2073: Histone deacetylase 8 impairs insulin sensitivity and activates β-catenin signaling in NAFLD-associated hepatocellular carcinoma
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation tightly associated with central obesity… 
2014
2014
HDAC8-Mediated Epigenetic Reprogramming Plays a Key Role in Resistance to Anthrax Lethal Toxin–Induced Pyroptosis in Macrophages
Macrophages pre-exposed to a sublethal dose of anthrax lethal toxin (LeTx) are refractory to subsequent high cytolytic doses of… 
2014
2014
This information is current as Pyroptosis in Macrophages Induced − Resistance to Anthrax Lethal Toxin Reprogramming Plays a Key Role in HDAC 8-Mediated Epigenetic
2010
2010
Abstract 5434: Development and biological characterization of novel, potent and stable isoform-specific inhibitors of histone deacetylase-8 (HDAC8)
Histone deacetylase (HDAC) inhibitors have shown promise for the treatment of hematological and solid tumors. The current… 
2008
2008
The Histone Deacetylase-8 (HDAC8) Selective Inhibitor PCI-34051 Decreases Interleukin-1 Beta Secretion in Vitro and Reduces Inflammation in Vivo
Inhibitors of histone deacetylases (HDACs) which are currently in clinical testing for treating various cancers typically inhibit… 
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