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Modulation of LMP1 protein expression by EBV-encoded microRNAs
- A. Lo, K. To, +4 authors S. Hayward
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 9 October 2007
Epstein–Barr virus (EBV) was the first human virus found to encode microRNAs (miRNAs), but the function of these miRNAs has been obscure. Nasopharyngeal carcinoma (NPC) is associated with EBV… Expand
Focus on nasopharyngeal carcinoma.
Support from the Hong Kong Research Grant Council (CUHK 4301/99M; 4071/02M; 4067/02M; 410/03M; and HKUST 2/03C) and the Kadoorie Charitable Foundation is gratefully acknowledged.
Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients.
- M. Chan, L. Chan, +8 authors K. To
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 February 2002
PURPOSE We aimed to investigate the methylation pattern in bladder cancer and assess the diagnostic potential of such epigenetic changes in urine. EXPERIMENTAL DESIGN The methylation status of 7… Expand
Acute renal impairment in coronavirus-associated severe acute respiratory syndrome
Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Background … Expand
An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival
- E. Choy, Kam-Leung Siu, +6 authors D. Jin
- Biology, Medicine
- The Journal of experimental medicine
- 27 October 2008
Epstein-Barr virus (EBV) is a herpesvirus associated with nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and other malignancies. EBV is the first human virus found to express microRNAs… Expand
Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.
BACKGROUND & AIMS By using methylation-sensitive representational difference analysis, we identified protocadherin 10 (PCDH10), a gene that encodes a protocadherin and is silenced in a tumor-specific… Expand
Human Metapneumovirus Detection in Patients with Severe Acute Respiratory Syndrome
We used a combination approach of conventional virus isolation and molecular techniques to detect human metapneumovirus (HMPV) in patients with severe acute respiratory syndrome (SARS). Of the 48… Expand
MET Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non–Small Cell Lung Carcinoma with Poor Prognosis
Purpose: Activation of MET oncogene as the result of amplification or activation mutation represents an emerging molecular target for cancer treatment. We comprehensively studied MET alterations and… Expand
Epstein-Barr virus infection alters cellular signal cascades in human nasopharyngeal epithelial cells.
Epstein-Barr virus (EBV) latent infection is a critical event in nasopharyngeal carcinoma (NPC) tumorigenesis. EBV-encoded genes have been shown to be involved in immune evasion and in the regulation… Expand
EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3).… Expand