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BACKGROUND & AIMS
Sirtuin 1 (SIRT1), the most conserved mammalian oxidized nicotinamide adenine dinucleotide-dependent protein… Expand The biothiols sensing mechanism of (E)-7-(diethylamino)-3-(2-nitrovinyl)-2H-chromen-2-one (DCO) has been investigated using the… Expand Background: The protein dimerization cofactor of HNF-1 (DCoH1)/pterin-carbinolamine dehydratase (PCD) accomplishes two unrelated… Expand ile acids (BAs) are amphipathic cholesterol derivaBtives that are produced in the liver and stored in the gallbladder. Because of… Expand The current paradigm for elucidating the molecular etiology of cancers relies on the interrogation of small numbers of genes… Expand The two disparate functions of DCoH1 (dimerization cofactor of HNF-1)/PCD (pterin-4a-carbinolamine dehydratase) are associated… Expand A large variety of biological processes is mediated by stimulation of the receptor tyrosine kinase MET. Screening a mouse embryo… Expand An inherited form of diabetes, maturity-onset diabetes of the young type 3 (MODY3), results from mutations in the transcriptional… Expand Mirk/Dyrk1B is an arginine-directed serine/threonine protein kinase that is expressed at low levels in most normal tissues but at… Expand The bifunctional protein DCoH (Dimerizing Cofactor for HNF1) acts as an enzyme in intermediary metabolism and as a binding… Expand