• DOI:10.1016/j.reprotox.2017.08.009
Corpus ID: 12985862

Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo

@article{Zhong2017HostGR,
  title={Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo},
  author={Y. Zhong and D. Liu and Mohamed M M Ahmed and Peng-hao Li and Xiaoling Zhou and Q. Xie and Xiaoqing Xu and Tingting Han and Zhi-Wei Hou and Chen-Yao Zhong and Ji-hua Huang and F. Zeng and T. Huang},
  journal={Reproductive Toxicology (Elmsford, N.y.)},
  year={2017},
  volume={73},
  pages={158 - 166}
}

Y. Zhong, D. Liu, +10 authors T. Huang

Published 2017

Biology, Medicine

Reproductive Toxicology (Elmsford, N.y.)

Abstract Hepatitis B virus (HBV) can invade the male germline, and sperm-introduced HBV genes could be transcribed in embryo. This study was to explore whether viral gene transcription is regulated by host genes. Embryos were produced by in vitro fertilization of hamster oocytes with human sperm containing the HBV genome. Total RNA extracted from test and control embryos were subjected to SMART-PCR, SSH, microarray hybridization, sequencing and BLAST analysis. Twenty-nine sequences showing… CONTINUE READING

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