Mechanism of action of fibrates on lipid and lipoprotein metabolism.
- B. Staels, J. Dallongeville, J. Auwerx, K. Schoonjans, E. Leitersdorf, J. Fruchart
- BiologyCirculation
- 10 November 1998
Both enhanced catabolism of triglyceride-rich particles and reduced secretion of VLDL underlie the hypotriglyceridemic effect of fibrates, whereas their effect on HDL metabolism is associated with changes in HDL apolipoprotein expression.
Role of bile acids and bile acid receptors in metabolic regulation.
- P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, B. Staels
- Biology, MedicinePhysiological Reviews
- 2009
Results suggest that modulation of FXR activity and BA metabolism may open new attractive pharmacological approaches for the treatment of the metabolic syndrome and type 2 diabetes.
Overview of Nomenclature of Nuclear Receptors
- P. Germain, B. Staels, C. Dacquet, M. Spedding, V. Laudet
- BiologyPharmacological Reviews
- 1 December 2006
The characterization of nuclear receptors and their associated proteins and the ligands that interact with them will remain a challenge to pharmacologists.
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression.
- K. Schoonjans, B. Staels, J. Auwerx
- BiologyJournal of Lipid Research
- 1 May 1996
It is suggested that PPARs are key messengers responsible for the translation of nutritional and pharmacological stimuli into changes in gene expression and differentiation pathways.
PPARalpha and PPARgamma activators direct a distinct tissueâspecific transcriptional response via a PPRE in the lipoprotein lipase gene.
- K. Schoonjans, J. Peinado-Onsurbe, J. Auwerx
- BiologyEMBO Journal
- 1 October 1996
Evidence is provided that transcriptional activation of the LPL gene by fibrates and thiazolidinediones is mediated by PPARâRXR heterodimers and contributes significantly to their hypotriglyceridemic effects in vivo.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- D. Klionsky, K. Abdelmohsen, S. Zughaier
- BiologyAutophagy
- 18 April 2012
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties.
- M. Bouhlel, B. Derudas, G. Chinetti-Gbaguidi
- BiologyCell Metabolism
- 8 August 2007
The Organization, Promoter Analysis, and Expression of the Human PPARÎł Gene*
- L. Fajas, D. Auboeuf, J. Auwerx
- Biology, ChemistryJournal of Biological Chemistry
- 25 July 1997
This work determined that high level expression of PPARÎł in colon warrants further study in view of the well established role of fatty acid and arachidonic acid derivatives in colonic disease and its promoters and tissue-specific expression were functionally characterized.
The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation.
- K. Schoonjans, B. Staels, J. Auwerx
- BiologyBiochimica et Biophysica Acta
- 26 July 1996
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
- L. Michalik, J. Auwerx, W. Wahli
- BiologyPharmacological Reviews
- 1 December 2006
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homologyâŚ
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