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PAX8 protein, human

Known as: paired box gene 8, human, paired domain gene 8, human, Pax-8 protein, human 
Paired box protein Pax-8 (450 aa, ~48 kDa) is encoded by the human PAX8 gene. This protein is involved in the differentiation of thyroid follicular… 
National Institutes of Health

Related topics

Related topics

14 relations
Cell NucleusDNA-Binding ProteinsGenes, RegulatorHistogenic Process

Broader (1)

PAX8 Transcription Factor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
PAX2 and PAX8 Expression in Primary and Metastatic Müllerian Epithelial Tumors: A Comprehensive Comparison
PAX2 and PAX8 are transcription factors that are essential in embryonic development of müllerian organs. They may also play a… 
Highly Cited
2010
Highly Cited
2010
PAX8 Reliably Distinguishes Ovarian Serous Tumors From Malignant Mesothelioma
Ovarian serous neoplasms can have morphologic overlap with malignant mesothelioma. The distinction is clinically important, yet… 
Highly Cited
2009
Highly Cited
2009
Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study
Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in embryonic, differentiated, or… 
Highly Cited
2008
Highly Cited
2008
Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms
Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation… 
Highly Cited
2006
Highly Cited
2006
Delineation, Functional Validation, and Bioinformatic Evaluation of Gene Expression in Thyroid Follicular Carcinomas with the PAX8-PPARG Translocation
A subset of follicular thyroid carcinomas contains a balanced translocation, t(2;3)(q13;p25), that results in fusion of the… 
Highly Cited
2005
Highly Cited
2005
PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations.
Thyroid dysgenesis (TD) is responsible for most cases of congenital hypothyroidism, a condition that affects about one in 4000… 
Highly Cited
2002
Highly Cited
2002
Pax2.1 is required for the development of thyroid follicles in zebrafish.
The thyroid gland is an organ primarily composed of endoderm-derived follicular cells. Although disturbed embryonic development… 
Highly Cited
2002
Highly Cited
2002
Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas.
Recently, a translocation t(2;3)(q13;p25), leading to the formation of a chimeric PAX8-peroxisome proliferator-activated receptor… 
Highly Cited
1998
Highly Cited
1998
Follicular cells of the thyroid gland require Pax8 gene function
The thyroid gland develops from two distinct embryonic lineages: follicular cells (which produce thyroxine) and parafollicular C… 
Highly Cited
1992
Highly Cited
1992
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors.
Recent evidence indicates a crucial role for paired box genes in mouse and human embryogenesis. The murine Pax8 gene encodes a… 
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