FAQ

PAX8 protein, human

Known as: paired box gene 8, human, paired domain gene 8, human, Pax-8 protein, human 
Paired box protein Pax-8 (450 aa, ~48 kDa) is encoded by the human PAX8 gene. This protein is involved in the differentiation of thyroid follicular… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2017
010203019922017

Related topics

Related topics

11 relations
Cell NucleusDNA-Binding ProteinsGenes, RegulatorHistogenic Process
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
PAX8 protein, human
Cell Nucleus
dna binding
Histogenic Process
Genes, Regulator
Transcriptional Regulation

Papers overview

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Highly Cited
2011
Highly Cited
2011
A comprehensive analysis of PAX8 expression in human epithelial tumors.
PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian, and renal/upper urinary tracts, and expression of… (More)
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2011
2011
Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study.
PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland… (More)
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Highly Cited
2010
Highly Cited
2010
PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma.
Ovarian serous neoplasms can have morphologic overlap with malignant mesothelioma. The distinction is clinically important, yet… (More)
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Highly Cited
2009
Highly Cited
2009
Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study
Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in embryonic, differentiated, or… (More)
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Highly Cited
2007
Highly Cited
2007
Emerging roles for PAX8 in ovarian cancer and endosalpingeal development.
OBJECTIVES Epithelial ovarian carcinomas develop from ovarian surface epithelia that undergo complex differentiation to form… (More)
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2003
2003
Involvement of the PAX8/peroxisome proliferator-activated receptor gamma rearrangement in follicular thyroid tumors.
Recently, a translocation t(2; 3)(q13;p25), involving the fusion of PAX8 and peroxisome proliferator-activated receptor gamma… (More)
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Highly Cited
2002
Highly Cited
2002
Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas.
Recently, a translocation t(2;3)(q13;p25), leading to the formation of a chimeric PAX8-peroxisome proliferator-activated receptor… (More)
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2001
2001
Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8.
Congenital hypothyroidism (CH) is a relatively frequent and potentially severe disease. It is classically subdivided into: 1… (More)
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Highly Cited
2000
Highly Cited
2000
PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas… (More)
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Highly Cited
1992
Highly Cited
1992
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors.
Recent evidence indicates a crucial role for paired box genes in mouse and human embryogenesis. The murine Pax8 gene encodes a… (More)
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