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Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
TLDR
A panel of four antibodies (ER, HER1, HER2, and cytokeratin 5/6) can accurately identify basal-like tumors using standard available clinical tools and shows high specificity. Expand
Characterization of the Early Lesion of ‘Degenerative’ Valvular Aortic Stenosis: Histological and Immunohistochemical Studies
TLDR
The early lesion of “degenerative” aortic stenosis is an active inflammatory process with some similarities (lipid deposition, macrophage and T-cell infiltration, and basement membrane disruption) and some dissimilarities (presence of prominent mineralization and small numbers of smooth muscle cells) to atherosclerosis. Expand
CDX2, a Highly Sensitive and Specific Marker of Adenocarcinomas of Intestinal Origin: An Immunohistochemical Survey of 476 Primary and Metastatic Carcinomas
TLDR
Uniform CDX2 expression is demonstrated to be an exquisitely sensitive and highly, but incompletely, specific marker of intestinal adenocarcinomas in primary and metastatic epithelial tumors. Expand
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.
TLDR
These guidelines are meant to be a practical diagnostic reference for the pathologist, however, some new pathologic predictors of prognosis and response to therapy are also included. Expand
Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group.
TLDR
These guidelines are meant to be a practical reference for the pathologist and take into account the localization of the stain and the percentage of cells staining in the diagnosis of MM. Expand
Specificity of HercepTest in determining HER-2/neu status of breast cancers using the United States Food and Drug Administration-approved scoring system.
TLDR
The results indicate that the HercepTest kit results in a large proportion of breast cancers being categorized as positive for HER-2/neu protein expression and that many of these seem to be false-positives. Expand
Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group.
TLDR
These guidelines are meant to be a practical reference for the pathologist and recommend that immunohistochemical markers have either sensitivity or specificity greater than 80% for the lesions in question. Expand
PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model
TLDR
Specific immunostaining for PDGF B-chain is found in neurons, principal dendrites, some axons, and probable terminals throughout the brain, in the dorsal horn of the spinal cord, and in the posterior pituitary of a nonhuman primate (Macaca nemestrina). Expand
HER-2 testing in breast cancer using parallel tissue-based methods.
TLDR
A testing algorithm for HER-2 determination is most efficient by using immunohistochemistry as the method of choice, with FISH performed for cancers with indeterminate results (2+ score). Expand
Poorly differentiated synovial sarcoma: immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors.
TLDR
The results showed PDSS to have significant immunophenotypic overlap with both PNETs and MPNSTs, and suggest that synovial sarcoma may be a tumor showing combined neuroectodermal and nerve sheath differentiation--rather than a carcinosarcoma of soft tissues or a tumor of specialized arthrogenous mesenchyme. Expand
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