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PAX3/FKHR Peptide Vaccine

Known as: PAX3/FKHR, PAX3/FKHR Fusion Peptide, PXFK 
A synthetic peptide vaccine based on the sequences of a translocation mutation of 2 transcriptional factor genes, PAX3 and FKHR. PAX3/FKHR fusion… 
National Institutes of Health

Related topics

Related topics

4 relations
Antigen SensitizationCytotoxic T-LymphocytesT-Cell Activationimmunopotentiation

Papers overview

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Highly Cited
2009
Highly Cited
2009
Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
Gene expression profiling has revealed that the gene coding for cannabinoid receptor 1 (CB1) is highly up-regulated in… 
2009
2009
Expression of Insulin-Like Growth Factor Pathway Proteins in Rhabdomyosarcoma: IGF-2 Expression is Associated with Translocation-Negative Tumors
Recent studies have shown a significant involvement of insulin-like growth factor (IGF) signaling components in the pathogenesis… 
Highly Cited
2008
Highly Cited
2008
Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities.
Inhibition of constitutive active signaling pathways, which are a characteristic phenomenon for many tumors, can be an effective… 
Highly Cited
2005
Highly Cited
2005
Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR
The oncogenic fusion protein, Pax3/FKHR, is a more potent transcription factor relative to its normal counterpart, Pax3. Since… 
Highly Cited
2004
Highly Cited
2004
Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1
Rhabdomyosarcoma is a pediatric tumor type, which is classified based on histological criteria into two major subgroups, namely… 
Highly Cited
2002
Highly Cited
2002
Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes
In this investigation, we selected PAX3/FKHR and PAX7/FKHR fusion transcript–positive and –negative alveolar rhabdomyosarcomas… 
2001
2001
Histology-Specific Expression of a DNA Repair Protein in Pediatric Rhabdomyosarcomas
Purpose DNA repair enzymes have a critical role in cellular maintenance and survival. The enzyme apurinic/apyrimidinic… 
Highly Cited
2000
Highly Cited
2000
Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR
The aberrant expression of the transcription factors PAX3 and PAX3/FKHR associated with rhabdomyosarcoma (RMS), solid tumors… 
Highly Cited
1995
Highly Cited
1995
Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma.
Cytogenetic analysis has defined specific translocations associated with two of the most common small round cell tumors of… 
Highly Cited
1995
Highly Cited
1995
The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.
Chimeric transcription factors, created by gene fusions as the result of chromosomal translocations, have been implicated in the… 
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