FAQ

PAN2 gene

Known as: PAN2, PAN2 poly(A) specific ribonuclease subunit, KIAA0710 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2017
02419872017

Related topics

Related topics

1 relation
ubiquitin-specific protease

Related mentions per year

Related mentions per year

1987-2018
19801990200020102020
PAN2 gene
ubiquitin-specific protease

Papers overview

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2014
2014
The structure of the Pan2–Pan3 core complex reveals cross-talk between deadenylase and pseudokinase
Pan2–Pan3 is a conserved complex involved in the shortening of mRNA poly(A) tails, the initial step in eukaryotic mRNA turnover… (More)
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2013
2013
Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.
The PAN2-PAN3 deadenylase complex functions in general and miRNA-mediated mRNA degradation and is specifically recruited to miRNA… (More)
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2010
2010
PUF3 acceleration of deadenylation in vivo can operate independently of CCR4 activity, possibly involving effects on the PAB1-mRNP structure.
The evolutionarily conserved PUF proteins stimulate CCR4 mRNA deadenylation through binding to 3' untranslated region sequences… (More)
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2009
2009
The role of deadenylation in the degradation of unstable mRNAs in trypanosomes
Removal of the poly(A) tail is the first step in the degradation of many eukaryotic mRNAs. In metazoans and yeast, the Ccr4/Caf1… (More)
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Highly Cited
2005
Highly Cited
2005
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover
In mammalian cells, the enzymatic pathways involved in cytoplasmic mRNA decay are incompletely defined. In this study, we have… (More)
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Highly Cited
2004
Highly Cited
2004
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E… (More)
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2004
2004
Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal.
The mouse CAF1 (mCAF1) is an ortholog of the yeast (y) CAF1 protein, which is a component of the CCR4-NOT complex, the major… (More)
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2004
2004
Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.
The poly(A) tail shortening in mRNA, called deadenylation, is the first rate-limiting step in eukaryotic mRNA turnover, and the… (More)
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1998
1998
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
As an extension of our cDNA analysis for deducing the coding sequences of unidentified human genes, we have newly determined the… (More)
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Highly Cited
1996
Highly Cited
1996
PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae.
The Pab1p-dependent poly(A) nuclease (PAN) from Saccharomyces cerevisiae copurifies with polypeptides of approximately 127 and 76… (More)
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