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PAN2 gene
Known as:
PAN2
, PAN2 poly(A) specific ribonuclease subunit
, KIAA0710
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National Institutes of Health
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Related topics
Related topics
1 relation
ubiquitin-specific protease
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay
S. Jonas
,
M. Christie
,
+5 authors
E. Izaurralde
Nature Structural &Molecular Biology
2014
Corpus ID: 7083
The PAN2–PAN3 complex functions in general and microRNA-mediated mRNA deadenylation. However, mechanistic insight into PAN2 and…
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2014
2014
The structure of the Pan2–Pan3 core complex reveals cross-talk between deadenylase and pseudokinase
Ingmar B. Schäfer
,
M. Rode
,
F. Bonneau
,
S. Schüssler
,
E. Conti
Nature Structural &Molecular Biology
2014
Corpus ID: 34436755
Pan2–Pan3 is a conserved complex involved in the shortening of mRNA poly(A) tails, the initial step in eukaryotic mRNA turnover…
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Highly Cited
2013
Highly Cited
2013
Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.
M. Christie
,
A. Boland
,
E. Huntzinger
,
O. Weichenrieder
,
E. Izaurralde
Molecular cell
2013
Corpus ID: 25797860
2010
2010
PUF3 acceleration of deadenylation in vivo can operate independently of CCR4 activity, possibly involving effects on the PAB1-mRNP structure.
Darren J. Lee
,
T. Ohn
,
+4 authors
C. Denis
Journal of molecular biology
2010
Corpus ID: 13286008
Highly Cited
2009
Highly Cited
2009
The role of deadenylation in the degradation of unstable mRNAs in trypanosomes
A. Schwede
,
Theresa Manful
,
+4 authors
C. Clayton
Nucleic acids research
2009
Corpus ID: 16598313
Removal of the poly(A) tail is the first step in the degradation of many eukaryotic mRNAs. In metazoans and yeast, the Ccr4/Caf1…
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Highly Cited
2008
Highly Cited
2008
Phosphorus cycling in the North and South Atlantic Ocean subtropical gyres
R. Mather
,
S. Reynolds
,
+7 authors
E. Achterberg
2008
Corpus ID: 56053506
Despite similar physical properties, the Northern and Southern Atlantic subtropical gyres have different biogeochemical regimes…
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Highly Cited
2005
Highly Cited
2005
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover
A. Yamashita
,
Tsung-Cheng Chang
,
+4 authors
A. Shyu
Nature Structural &Molecular Biology
2005
Corpus ID: 19485927
In mammalian cells, the enzymatic pathways involved in cytoplasmic mRNA decay are incompletely defined. In this study, we have…
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Highly Cited
2004
Highly Cited
2004
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.
J. Damiano
,
Vasco A. Oliveira
,
K. Welsh
,
John Calvin Reed
The Biochemical journal
2004
Corpus ID: 25714935
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E…
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Highly Cited
2004
Highly Cited
2004
Mouse CAF1 Can Function As a Processive Deadenylase/3′–5′-Exonuclease in Vitro but in Yeast the Deadenylase Function of CAF1 Is Not Required for mRNA Poly(A) Removal*
P. Viswanathan
,
T. Ohn
,
Y. Chiang
,
Junji Chen
,
C. Denis
Journal of Biological Chemistry
2004
Corpus ID: 37314738
The mouse CAF1 (mCAF1) is an ortholog of the yeast (y) CAF1 protein, which is a component of the CCR4-NOT complex, the major…
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Highly Cited
1998
Highly Cited
1998
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
K. Ishikawa
,
T. Nagase
,
+5 authors
O. Ohara
DNA research : an international journal for rapid…
1998
Corpus ID: 37740536
As an extension of our cDNA analysis for deducing the coding sequences of unidentified human genes, we have newly determined the…
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