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PAN2 gene

Known as: PAN2, PAN2 poly(A) specific ribonuclease subunit, KIAA0710 
National Institutes of Health

Related topics

Related topics

1 relation
ubiquitin-specific protease

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay
The PAN2–PAN3 complex functions in general and microRNA-mediated mRNA deadenylation. However, mechanistic insight into PAN2 and… 
2014
2014
The structure of the Pan2–Pan3 core complex reveals cross-talk between deadenylase and pseudokinase
Pan2–Pan3 is a conserved complex involved in the shortening of mRNA poly(A) tails, the initial step in eukaryotic mRNA turnover… 
Highly Cited
2013
Highly Cited
2013
Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.
2010
2010
PUF3 acceleration of deadenylation in vivo can operate independently of CCR4 activity, possibly involving effects on the PAB1-mRNP structure.
Highly Cited
2009
Highly Cited
2009
The role of deadenylation in the degradation of unstable mRNAs in trypanosomes
Removal of the poly(A) tail is the first step in the degradation of many eukaryotic mRNAs. In metazoans and yeast, the Ccr4/Caf1… 
Highly Cited
2008
Highly Cited
2008
Phosphorus cycling in the North and South Atlantic Ocean subtropical gyres
Despite similar physical properties, the Northern and Southern Atlantic subtropical gyres have different biogeochemical regimes… 
Highly Cited
2005
Highly Cited
2005
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover
In mammalian cells, the enzymatic pathways involved in cytoplasmic mRNA decay are incompletely defined. In this study, we have… 
Highly Cited
2004
Highly Cited
2004
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E… 
Highly Cited
2004
Highly Cited
2004
Mouse CAF1 Can Function As a Processive Deadenylase/3′–5′-Exonuclease in Vitro but in Yeast the Deadenylase Function of CAF1 Is Not Required for mRNA Poly(A) Removal*
The mouse CAF1 (mCAF1) is an ortholog of the yeast (y) CAF1 protein, which is a component of the CCR4-NOT complex, the major… 
Highly Cited
1998
Highly Cited
1998
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
As an extension of our cDNA analysis for deducing the coding sequences of unidentified human genes, we have newly determined the… 
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