Skip to search formSkip to main contentSkip to account menu

PAK4 gene

Known as: KIAA1142, p21 PROTEIN-ACTIVATED KINASE 4, p21 CDC42/RAC1-ACTIVATED KINASE 4 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Repression of choroidal neovascularization through actin cytoskeleton pathways by microRNA-24.
Actin cytoskeleton is critical for cell motility and division, both of which are important for angiogenesis. MicroRNAs (miRNA/miR… 
2013
2013
NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1.
Highly Cited
2012
Highly Cited
2012
Differential Expression of Key Signaling Proteins in MCF10 Cell Lines, a Human Breast Cancer Progression Model.
Breast cancer is a heterogeneous disease that develops through a multistep process whose molecular basis remains poorly… 
2012
2012
The Pak4 Protein Kinase in Breast Cancer
Paks4, along with Paks5, and 6 are members of the group B family of p21-activated kinases (Paks). The Paks play multiple… 
Highly Cited
2011
Highly Cited
2011
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma.
Gestational trophoblastic disease (GTD) includes frankly malignant choriocarcinoma (CCA) and placental site trophoblastic tumor… 
2011
2011
PAK4 is required for regulation of the cell‐cycle regulatory protein p21, and for control of cell‐cycle progression
The serine/threonine kinase PAK4 regulates cytoskeletal architecture, and controls cell proliferation and survival. In most adult… 
2007
2007
Functional protein kinase arrays reveal inhibition of p‐21‐activated kinase 4 by α‐synuclein oligomers
There is increasing evidence that aggregation of α‐synuclein contributes to the functional and structural deterioration in the… 
2004
2004
Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.
Highly Cited
2003
Highly Cited
2003
p21-activated Protein Kinase 4 (PAK4) Interacts with the Keratinocyte Growth Factor Receptor and Participates in Keratinocyte Growth Factor-mediated Inhibition of Oxidant-induced Cell Death*
Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family (also known as FGF-7), is an important… 
Highly Cited
2002
Highly Cited
2002
p21-activated kinase 4 interacts with integrin αvβ5 and regulates αvβ5-mediated cell migration
p21-activated kinase 1 (PAK1) can affect cell migration (Price et al., 1998; del Pozo et al., 2000) and modulate myosin light… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)