PAK4/NAMPT Inhibitor KPT-9274

Known as: KCP-9274, KPT-9274 
An orally bioavailable inhibitor of both the serine/threonine kinase P21-activated kinase 4 (PAK4) and the nicotinamide adenine dinucleotide (NAD… (More)

Topic mentions per year

Topic mentions per year

2016-2018
0120162018

Papers overview

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2018
2018
Although substantial progress has been made in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), the prognosis of… (More)
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2017
2017
Breast cancer is a heterogeneous disease consisting of several subtypes. Among these subtypes, triple negative breast cancer is… (More)
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2017
2017
The p21-activated kinase 4 (PAK4) is a key downstream effector of the Rho family GTPases and is found to be overexpressed in… (More)
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2017
2017
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and therapy resistant malignancy. Mutant K-Ras, found in >90% of… (More)
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2017
2017
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary renal disease with no currently available targeted… (More)
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2017
2017
The 6 hallmarks of cancer highlight the quintessential role kinases play in the signal transduction across complex and… (More)
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2017
2017
Dysregulated oncogenic serine/threonine kinases play a pathological role in diverse forms of malignancies, including multiple… (More)
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2017
2017
Unraveling the mechanism of action and molecular target of small molecules remains a major challenge in drug discovery. While… (More)
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2016
2016
Kidney cancer (or renal cell carcinoma, RCC) is the sixth most common malignancy in the United States and one of the relatively… (More)
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