Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation.

@article{Arowosegbe2019KaempferolAA,
  title={Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation.},
  author={Michael A Arowosegbe and Oluwamuyiwa T Amusan and Segun A Adeola and O. B. Adu and Israel A Akinola and Bimpe Folasade Ogungbe and Olaposi I Omotuyi and Gbemisola M Saibu and Adewale J. Ogunleye and Ramon I Kanmodi and Nekabari E Lugbe and Oluwafemi Jude Ogunmola and Damilola Ajayi and Sedoten O Ogun and Faith O Oyende and Ahmed O Bello and Abudulmalik O Ishola and Patrick E Obasieke},
  journal={Current drug discovery technologies},
  year={2019}
}
BACKGROUND P-21 activating kinase 4 (PAK4) is implicated in poor prognosis of many human tumors, particularly in triple negative breast cancer (TNBC) progression. Studies have revealed the crucial role of PAK4 in cell proliferation, anchorage-independent growth and cell migration among other hallmarks of cancer. Thus, PAK4 is an attractive target for anti-TNBC drug design and development. In our research, we used in silico methods to investigate the inhibitory potentials of kaempferol against… CONTINUE READING