Skip to search formSkip to main contentSkip to account menu

P 1075

Known as: P-1075, P1075 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression.
Highly Cited
2003
Highly Cited
2003
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
2002
2002
Interaction of K(ATP) channel modulators with sulfonylurea receptor SUR2B: implication for tetramer formation and allosteric coupling of subunits.
Sulfonylurea receptors (SURs) are subunits of ATP-sensitive K(+) channels (K(ATP) channels); they mediate the channel-closing… 
Highly Cited
2001
Highly Cited
2001
Functional Roles of Cardiac and Vascular ATP-Sensitive Potassium Channels Clarified by Kir6.2-Knockout Mice
Abstract— ATP-sensitive potassium (KATP) channels were discovered in ventricular cells, but their roles in the heart remain… 
Highly Cited
2001
Highly Cited
2001
Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: differences in the coupling to Kir6.x subtypes.
ATP-dependent K(+) channels are composed of pore-forming subunits of the Kir6.x family and of sulfonylurea receptors (SURs). SUR1… 
Highly Cited
2000
Highly Cited
2000
Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.
ATP-sensitive K-channels (K(ATP) channels) are the target for K(ATP)-channel openers (KCOs), such as pinacidil and P1075. These… 
Highly Cited
1999
Highly Cited
1999
Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells.
ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. To investigate the… 
Highly Cited
1999
Highly Cited
1999
Coexpression with the inward rectifier K(+) channel Kir6.1 increases the affinity of the vascular sulfonylurea receptor SUR2B for glibenclamide.
ATP-sensitive K(+) channels are closed by the hypoglycemic sulfonylureas like glibenclamide (GBC) and activated by a class of… 
Highly Cited
1993
Highly Cited
1993
Binding of the K+ channel opener [3H]P1075 in rat isolated aorta: relationship to functional effects of openers and blockers.
P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N"-3-pyridylguanidine], an analogue of the K+ channel opener pinacidil, was shown to be a… 
Highly Cited
1992
Highly Cited
1992
Antiarrhythmic Effects of Potassium Channel Openers in Rhythm Abnormalities Related to Delayed Repolarization
Background Earlier observations have indicated that repolarization-delaying agents may, under certain circumstances, have the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)