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Inhalational anesthetics activate two-pore-domain background K+ channels
It is shown that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics. Expand
Properties and modulation of mammalian 2P domain K+ channels
The pharmacological modulation of this novel class of ion channels could be of interest for both general anaesthesia and ischaemic neuroprotection. Expand
A mammalian two pore domain mechano‐gated S‐like K+ channel
A cloned mammalian two P domain K+ channel sharing the properties of the S channel is identified and it is found that the cytoplasmic C‐terminus contains a charged region critical for chemical and mechanical activation, as well as a phosphorylation site required for cAMP inhibition. Expand
An oxygen‐, acid‐ and anaesthetic‐sensitive TASK‐like background potassium channel in rat arterial chemoreceptor cells
The pharmacological and biophysical properties of the background K+ channel of rat carotid body type‐I cells are analogous to those of the cloned channel TASK‐1, and it is concluded that the oxygen‐ and acid‐sensitive background K+, likely to be an endogenous TASk‐1‐like channel. Expand
The neuronal background K2P channels: focus on TREK1
  • E. Honoré
  • Chemistry, Medicine
  • Nature Reviews Neuroscience
  • 1 April 2007
Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane segments and two pore-forming domains that are arranged in tandem and function as either homo- or heterodimeric channels.Expand
The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1
It is demonstrated that TASK‐1, unlike the other two pore (2P) domain K+ channels, is directly blocked by submicromolar concentrations of the endocannabinoid anandamide, independently of the CB1 and CB2 receptors. Expand
TREK‐1 is a heat‐activated background K+ channel
Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres asExpand
Kv2.1/Kv9.3, a novel ATP‐dependent delayed‐rectifier K+ channel in oxygen‐sensitive pulmonary artery myocytes
It is proposed that metabolic regulation of the Kv2.1/Kv9.3 heteromultimer may play an important role in hypoxic PA vasoconstriction and in the possible development of PA hypertension. Expand
An intracellular proton sensor commands lipid‐ and mechano‐gating of the K+ channel TREK‐1
It is concluded that protonation of E306 tunes the TREK‐1 mechanical setpoint and thus sets lipid sensitivity, and the cAMP/PKA down‐modulation is abolished. Expand
A phospholipid sensor controls mechanogating of the K+ channel TREK‐1
It is demonstrated that membrane phospholipids, including PIP2, control channel gating and transform TREK‐1 into a leak K+ conductance. Expand