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Inhalational anesthetics activate two-pore-domain background K+ channels
Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an inhibitory synapticExpand
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A mammalian two pore domain mechano‐gated S‐like K+ channel
Aplysia S‐type K+ channels of sensory neurons play a dominant role in presynaptic facilitation and behavioural sensitization. They are closed by serotonin via cAMP‐dependent phosphorylation, whereasExpand
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Properties and modulation of mammalian 2P domain K+ channels
Mammalian 2P domain K(+) channels are responsible for background or 'leak' K(+) currents. These channels are regulated by various physical and chemical stimuli, including membrane stretch,Expand
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The neuronal background K2P channels: focus on TREK1
  • E. Honoré
  • Chemistry, Medicine
  • Nature Reviews Neuroscience
  • 1 April 2007
Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane segments and two pore-forming domains that are arranged in tandem and function as either homo- or heterodimeric channels.Expand
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An oxygen‐, acid‐ and anaesthetic‐sensitive TASK‐like background potassium channel in rat arterial chemoreceptor cells
1 The biophysical and pharmacological properties of an oxygen‐sensitive background K+ current in rat carotid body type‐I cells were investigated and compared with those of recently cloned two poreExpand
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TREK‐1 is a heat‐activated background K+ channel
Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres asExpand
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The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1
TASK‐1 encodes an acid‐ and anaesthetic‐sensitive background K+ current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate thatExpand
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Kv2.1/Kv9.3, a novel ATP‐dependent delayed‐rectifier K+ channel in oxygen‐sensitive pulmonary artery myocytes
The molecular structure of oxygen‐sensitive delayed‐rectifier K+ channels which are involved in hypoxic pulmonary artery (PA) vasoconstriction has yet to be elucidated. To address this problem, weExpand
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A phospholipid sensor controls mechanogating of the K+ channel TREK‐1
TREK‐1 (KCNK2 or K2P2.1) is a mechanosensitive K2P channel that is opened by membrane stretch as well as cell swelling. Here, we demonstrate that membrane phospholipids, including PIP2, controlExpand
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An intracellular proton sensor commands lipid‐ and mechano‐gating of the K+ channel TREK‐1
The 2P domain K+ channel TREK‐1 is widely expres sed in the nervous system. It is opened by a variety of physical and chemical stimuli including membrane stretch, intracellular acidosis andExpand
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