Osteonectin

Known as: Basement-Membrane Protein 40, SPARC Glycoprotein, Osteonectin [Chemical/Ingredient] 
Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The matricellular protein osteonectin, secreted protein acidic and rich in cysteine (SPARC, BM-40), is the most abundant non… (More)
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Highly Cited
2008
Highly Cited
2008
Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal… (More)
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Highly Cited
2003
Highly Cited
2003
Deregulated expression of SPARC/osteonectin, a secreted glycoprotein with multiple biological functions, has been associated with… (More)
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Highly Cited
2000
Highly Cited
2000
Bone continuously remodels in response to mechanical and physiological stresses, allowing vertebrates to renew bone as adults… (More)
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Highly Cited
2000
Highly Cited
2000
The precise mechanism(s) involved in invasion and metastasis of prostate cancer (CaP) is poorly understood. Osteonectin [ON (also… (More)
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Highly Cited
1999
Highly Cited
1999
The mechanism underlying the "organ-specific" metastasis of prostate cancer cells to the bone is still poorly understood. It is… (More)
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Highly Cited
1998
Highly Cited
1998
Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular… (More)
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Highly Cited
1998
Highly Cited
1998
SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin/BM40) is a secreted Ca2+-binding glycoprotein that… (More)
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Highly Cited
1988
Highly Cited
1988
2ar has been identified as a gene inducible by tumor promoters and growth factors in a variety of cultured mouse cell lines… (More)
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Highly Cited
1981
Highly Cited
1981
Osteonectin is a 32,000 dalton bone-specific protein that binds selectively to both hydroxyapatite and collagen. When osteonectin… (More)
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