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Osteonectin

Known as: Basement-Membrane Protein 40, SPARC Glycoprotein, Osteonectin [Chemical/Ingredient] 
Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein… 
National Institutes of Health

Related topics

Related topics

22 relations
Bone remodelingCalcium BindingCell Cycle ControlExtracellular Matrix

Broader (2)

Extracellular Matrix ProteinsGlycoproteins

Narrower (3)

SMOC-1 protein, mouseSMOC-1 protein, ratSMOC1 protein, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk.
The interplay between peritoneal mesothelial cells and ovarian cancer cells is critical for the initiation and peritoneal… 
Highly Cited
2006
Highly Cited
2006
SPARC-induced migration of glioblastoma cell lines via uPA-uPAR signaling and activation of small GTPase RhoA.
Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in human gliomas where it promotes invasion and delays… 
2001
2001
Glass reinforced hydroxyapatite for hard tissue surgery--part II: in vitro evaluation of bone cell growth and function.
Highly Cited
2000
Highly Cited
2000
Expression and characterization of SPARC in human lens and in the aqueous and vitreous humors.
SPARC (secreted protein, acidic and rich in cysteine) is a matricellular glycoprotein that regulates morphogenesis, cellular… 
Highly Cited
1996
Highly Cited
1996
Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly.
Focal adhesions are specialized regions of cell membranes that are foci for the transmission of signals between the outside and… 
Highly Cited
1992
Highly Cited
1992
Trans-differentiation of hypertrophic chondrocytes into cells capable of producing a mineralized bone matrix.
Highly Cited
1991
Highly Cited
1991
Recombinant expression and properties of the human calcium-binding extracellular matrix protein BM-40.
A cDNA construct (approximately 1 kb) of human BM-40 in a plasmid with the cytomegalovirus promoter and enhancer was used to… 
Highly Cited
1990
Highly Cited
1990
Characterization of a novel calcium-binding 90-kDa glycoprotein (BM-90) shared by basement membranes and serum.
The protein BM-90 was solubilized from the mouse Engelbreth-Holm-Swarm tumor with neutral buffers in molar yields lower (15-30… 
Review
1990
Review
1990
Cellular activity, matrix proteins, and aging bone
Highly Cited
1988
Highly Cited
1988
Gene expression in mineralizing chick epiphyseal cartilage.
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