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OTX008

Known as: Gal-1 Inhibitor OTX008, Galectin-1 Inhibitor OTX008 
A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. Upon subcutaneous… 
National Institutes of Health

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Papers overview

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2018
2018
Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells
Background/Aims: Immune tolerance is considered the only way to manage liver transplantation (LT). The current study hypothesized… 
2016
2016
Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 “Nanoplex” a Possible Neurotherapeutic?
Galectins are a family of β-galactoside-binding lectins that are important modulators of homeostasis in the central nervous… 
2016
2016
Circulating and tissue galectin-1 and galectin-3 in colorectal carcinoma: association with clinicopathological parameters, serum CEA, IL-17 and IL23.
PURPOSE Galectins are modulators of many processes critical for tumor progression and metastasis but their clinical significance… 
2016
2016
Deep phylogenomics of a tandem-repeat galectin regulating appendicular skeletal pattern formation
A multiscale network of two galectins Galectin-1 (Gal-1) and Galectin-8 (Gal-8) patterns the avian limb skeleton. Among… 
2015
2015
Galectin‐1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice
Galectin‐1, a member of the β‐galactoside‐binding lectin family, accumulates in neurofilamentous lesions in the spinal cords of… 
2010
2010
Galectin-1 is expressed in early type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus
Highly Cited
2008
Highly Cited
2008
Severe preeclampsia is characterized by increased placental expression of galectin-1
Objective. Galectin-1 is a major anti-inflammatory protein expressed by the placenta and immune cells that can bias the character… 
2003
2003
Decreased galectin-1 immunoreactivity of the skin in amyotrophic lateral sclerosis
2001
2001
The function recovery of aged brain and nervous system by new nerve activator. New neuranagenesis modulator, oxidic Galectin-1. ( Yokohama City Univ. school of medicine ).
Highly Cited
1996
Highly Cited
1996
Characterization of monomeric forms of galectin-1 generated by site-directed mutagenesis.
Galectin-1 is a beta-galactoside-binding protein secreted by animal cells, and it exists in a monomer-dimer equilibrium (Kd… 
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