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Epidemiology and causes of preterm birth
TLDR
A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth. Expand
Soluble endoglin contributes to the pathogenesis of preeclampsia
TLDR
A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia. Expand
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
TLDR
Rising circulating levels of soluble endoglin and ratios of sFlt1:PlGF herald the onset of preeclampsia, which was greatest among women in the highest quartile of the control distributions for both biomarkers but not for either biomarker alone. Expand
The fetal inflammatory response syndrome.
TLDR
The fetal systemic inflammatory response as a mechanism of disease is reviewed and potential interventions to control an exaggerated inflammatory response in utero are also described. Expand
The preterm parturition syndrome
TLDR
The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related). Expand
Pre-eclampsia part 1: current understanding of its pathophysiology
TLDR
The diagnosis, classification, clinical manifestations and putative pathogenetic mechanisms of pre-eclampsia are discussed. Expand
Preterm labor: One syndrome, many causes
TLDR
The current understanding of the mechanisms of disease implicated in preterm labor are summarized and advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance are reviewed. Expand
The role of inflammation and infection in preterm birth.
TLDR
The role of inflammation in preterm and term parturition is reviewed, which is the only pathological process for which both a firm causal link with preterm birth and a molecular pathophysiology defined are established. Expand
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients
TLDR
The objective of this study was to determine if changes in maternal plasma concentration of these angiogenic and anti-angiogenic factors differ prior to development of disease among patients with normal pregnancies and those destined to develop PE (preterm and term) or to deliver a small for gestational age (SGA) neonate. Expand
Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double‐blind, placebo‐controlled trial
TLDR
The efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix is determined. Expand
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