ORG 3770

Nocturnal plasma melatonin concentration was significantly increased in ten normal volunteers following the administration of an… Expand

90 patients between 18 and 65 years, with a DSM-III diagnosis of moderate or severe major depressive episode, were randomized to… Expand

BACKGROUND A 6-week, double-blind, dose titration study was performed to evaluate efficacy and safety of the new antidepressant… Expand

SummaryMirtazapine (Org 3770) is a selective antagonist at α2-adrenergic auto- and heteroreceptors, which are involved in… Expand

Mirtazapine (Org 3770, Remeron) is a new alpha2-adrenoceptor antagonist which is an effective antidepressant drug. An in vivo… Expand

The antidepressant properties of Org 3770 (1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3- c][2]benzazepine) may be… Expand

SummaryThe effect of a single dose (30 mg) of Org 3770 (metirzapine) on human sleep was assessed in a double blind, placebo… Expand

Actions and interactions of two antidepressants and diazepam on human skilled performance and mood were studied in a randomized… Expand

The neurochemical and autonomic pharmacological profile of 1,2,3,4,10, 14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c]pyrido… Expand

Two hundred and fifty female patients about to undergo elective gynaecological surgery, were randomly allocated to a single oral… Expand