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Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine
The high dose of pilocarpine induces oxidative damage and increases antioxidant enzyme activities and expression in brain cortex and increased lipid peroxidation produces the consumption of Vitamin E. Expand
Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
The fact that melatonin and resveratrol are present in various foods, exhibiting possible synergistic effects, suggests the use of dietary ingredients to promote health and longevity. Expand
The trivial function of sleep.
It is argued that the function of sleep could be trivial for mammals and birds because sleep does not provide additional advantages over simple rest, and it is proposed that few, if any, phenotypic selectable traits do exist in sleep. Expand
Activation and desensitization by cyclic antidepressant drugs of α2-autoreceptors, α2-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo
These findings indicate that acute treatment with cyclic antidepressant drugs results in activation of inhibitory α2C-autoreceptors, α2A-heteroreceptorors and/or 5-HT1A-autorceptors regulating the synthesis of dopa/NA or 5- HTP/5-HT after chronic desipramine and fluoxetine. Expand
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
The positive effects of polyphenols on the prevention of the changes that occur during aging in the brain and their consequences on cognition are described, emphasizing the possible modulation of inflammaging bypolyphenols through a SIRT1-mediated mechanism. Expand
Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain
Brain monoamines are involved in many neurochemical and behavioral effects of cannabinoids, but little is known on the regulation of noradrenaline, dopamine, and serotonin (5-HT) synthesis inExpand
The imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline is a dopamine-releasing agent in the rat striatum in vivo
The I2-imidazoline receptor ligand 2-BFI is also a DA releasing agent in brain, and consequently a DA indirect agonist in vivo. Expand
Ethanol desensitizes cannabinoid CB1 receptors modulating monoamine synthesis in the rat brain in vivo
Treatment with ethanol in rats induces a functional desensitization of CB(1) receptors modulating the synthesis of brain monoamines, and the inhibitory effect of WIN 55,212-2 on 5-HTP/5-HT synthesis was reduced or abolished in the three brain regions after chronic ethanol and during withdrawal. Expand
Age-related changes in circadian rhythm of serotonin synthesis in ring doves: Effects of increased tryptophan ingestion
The results suggest that the supplemental administration of tryptophan might aid to improve the descent in 5-HT that normally occurs, as animals get old. Expand
Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats
This study suggests resveratrol treatment as a restoring therapy for the impaired cognitive functions occurring along normal aging process, by preventing 5-HT, DA, and NA neurotransmission decline. Expand