ORAI1 gene

Known as: ORAI Calcium Release-Activated Calcium Modulator 1 Gene, FLJ14466, CRACM1 
This gene plays a role in calcium transport and T-cell-mediated immune responses.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Store-operated Ca(2+) channels activated by the depletion of Ca(2+) from the endoplasmic reticulum (ER) are a major Ca(2+) entry… (More)
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Highly Cited
2009
Highly Cited
2009
Tumor metastasis is the primary cause of death of cancer patients. Understanding the molecular mechanisms underlying tumor… (More)
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Highly Cited
2009
Highly Cited
2009
In immune cells, generation of sustained Ca(2+) levels is mediated by the Ca(2+) release-activated Ca(2+) (CRAC) current… (More)
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Highly Cited
2008
Highly Cited
2008
STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however… (More)
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Highly Cited
2008
Highly Cited
2008
The receptor-evoked Ca(2+) signal includes activation of the store-operated channels (SOCs) TRPCs and the Orais. Although both… (More)
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Highly Cited
2008
Highly Cited
2008
Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels initiates key functions such as gene… (More)
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Highly Cited
2006
Highly Cited
2006
Stimulation of immune cells causes depletion of Ca2+ from endoplasmic reticulum (ER) stores, thereby triggering sustained Ca2… (More)
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Highly Cited
2006
Highly Cited
2006
Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels, promoting the immune… (More)
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Highly Cited
2006
Highly Cited
2006
The two membrane proteins, STIM1 and Orai1, have each been shown to be essential for the activation of store-operated channels… (More)
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Highly Cited
2006
Highly Cited
2006
The molecular nature of store-operated Ca(2+)-selective channels has remained an enigma, due largely to the continued inability… (More)
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