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ORAI1 gene

Known as: ORAI Calcium Release-Activated Calcium Modulator 1 Gene, FLJ14466, CRACM1 
This gene plays a role in calcium transport and T-cell-mediated immune responses.
National Institutes of Health

Related topics

Related topics

9 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Narrower (1)

ORAI1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Orai1 pore residues control CRAC channel inactivation independently of calmodulin
Researchers have reevaluated the role of calmodulin and previously identified calmodulin binding sites in the mechanism by which… 
Highly Cited
2015
Highly Cited
2015
STIM1L traps and gates Orai1 channels without remodeling the cortical ER
STIM proteins populate and expand cortical endoplasmic reticulum (ER) sheets to mediate store‐operated Ca2+ entry (SOCE) by… 
2014
2014
The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic compensation and the development of dilated cardiomyopathy
As exceptionally calcium selective store-operated channels, Orai channels play a prominent role in cellular calcium signaling… 
2012
2012
Distinct Contributions of Orai1 and TRPC1 to Agonist-Induced [Ca2+]i Signals Determine Specificity of Ca2+-Dependent Gene Expression
Regulation of critical cellular functions, including Ca2+-dependent gene expression, is determined by the temporal and spatial… 
Review
2012
Review
2012
Structure, regulation and biophysics of I(CRAC), STIM/Orai1.
Ca(2+) release activated Ca(2+) (CRAC) channels mediate robust Ca(2+) influx when the endoplasmic reticulum Ca(2+) stores are… 
Highly Cited
2011
Highly Cited
2011
Photonic Generation of Phase-Coded Microwave Signal With Large Frequency Tunability
A photonic approach to realizing phase-coded microwave signal generation with large frequency tunability is proposed and… 
Highly Cited
2010
Highly Cited
2010
Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis
Orai1 trafficking between the cell membrane and endosomes during meiosis requires caveolin and is important for tuning calcium… 
Highly Cited
2009
Highly Cited
2009
Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel
A general cellular response following depletion of intracellular calcium stores involves activation of store-operated channels… 
2009
2009
Bombyx mori Homologs of STIM1 and Orai1 Are Essential Components of the Signal Transduction Cascade That Regulates Sex Pheromone Production*
Sex pheromone production in the pheromone gland (PG) of the silkmoth, Bombyx mori, is mediated by store-operated channels (SOCs… 
Review
2007
Review
2007
The long and arduous road to CRAC.
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