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OPTC gene

Known as: OPTC, OPTICIN, oculoglycan 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Characterization of opticin digestion by proteases involved in osteoarthritis development.
2012
2012
Opticin Exerts Its Anti-angiogenic Activity by Regulating Extracellular Matrix Adhesiveness
Background: Recently, we demonstrated that the glycoprotein opticin is anti-angiogenic. Here, the underpining mechanism is… 
Highly Cited
2011
Highly Cited
2011
Identification of differentially expressed proteins in the aqueous humor of primary congenital glaucoma.
2008
2008
Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis.
Highly Cited
2007
Highly Cited
2007
Role of CYP1B1, MYOC, OPTN and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients
Purpose Mutations in the CYP1B1, MYOC, OPTN, and WDR36 genes result in glaucoma. Given its expression in the optic nerve, it is… 
Highly Cited
2007
Highly Cited
2007
Novel mutations in the small leucine‐rich repeat protein/proteoglycan (SLRP) genes in high myopia
The importance of the genetic component in high myopia has been well established in population and family studies, but only a few… 
Highly Cited
2005
Highly Cited
2005
Opticin binds to heparan and chondroitin sulfate proteoglycans.
PURPOSE The extracellular matrix glycoprotein opticin is a small leucine-rich repeat proteoglycan/protein family member that was… 
Highly Cited
2003
Highly Cited
2003
Opticin binds retinal growth hormone in the embryonic vitreous.
PURPOSE Opticin is a small leucine-rich repeat proteoglycan that is abundant in several ocular tissues, including the vitreous… 
2003
2003
Characterization of Opticin and Evidence of Stable Dimerization in Solution*
Opticin is a class III member of the extracellular matrix small leucine-rich repeat protein (SLRP) family that was initially… 
Highly Cited
2001
Highly Cited
2001
Structure, chromosomal location, and tissue-specific expression of the mouse opticin gene.
PURPOSE To determine the structure, location, and tissue-specific expression of the mouse opticin gene (Optc) and to compare… 
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