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Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.
The vertebrate lens provides an excellent model to study the mechanisms that regulate terminal differentiation. Although fibroblast growth factors (FGFs) are thought to be important for lens cell… Expand
Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation.
PURPOSE To report vitreous oxygen tension before, immediately after, and at longer times after vitrectomy. DESIGN A prospective, interventional consecutive case series. METHODS Oxygen was… Expand
FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands
Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctival and eyelid epithelia and produce secretions that lubricate and protect the ocular surface. Sox9 expression… Expand
Coincident loss of mitochondria and nuclei during lens fiber cell differentiation
During normal differentiation, lens fiber cells lose their nuclei, mitochondria, and other membrane‐bound organelles. In the present study, a slice preparation of the embryonic chicken lens was used… Expand
Oxidative Damage and the Prevention of Age-Related Cataracts
Purpose: Cataracts are often considered to be an unavoidable consequence of aging. Oxidative damage is a major cause or consequence of cortical and nuclear cataracts, the most common types of… Expand
Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2.
- T. J. Schoen, K. Mazuruk, +4 authors I. R. Rodriguez
- Biology, Medicine
- Journal of molecular endocrinology
- 1 August 1995
We have isolated and characterized a cDNA for IGF-binding protein-2 (IGFBP-2) and its gene from the chick embryo. Using primers from a conserved region of the mammalian IGFBP-2 sequence, a cDNA clone… Expand
The mechanism of lens placode formation: a case of matrix-mediated morphogenesis.
Although placodes are ubiquitous precursors of tissue invagination, the mechanism of placode formation has not been established and the requirement of placode formation for subsequent invagination… Expand
The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.
BMPs play multiple roles in development and BMP signaling is essential for lens formation. However, the mechanisms by which BMP receptors function in vertebrate development are incompletely… Expand
Development of the ciliary body: a brief review.
- D. Beebe
- Transactions of the ophthalmological societies of…
The ciliary body is an important component in the tissue interactions that occur during the normal development of the eye. The ciliary epithelium is induced by the lens from the rim of the optic cup… Expand
Oxygen distribution in the rabbit eye and oxygen consumption by the lens.
- Ying-Bo Shui, Jia-Jan Fu, +7 authors D. Beebe
- Medicine, Biology
- Investigative ophthalmology & visual science
- 1 April 2006
PURPOSE Excessive exposure to oxygen has been proposed to be a risk factor for nuclear cataracts. For a better understanding of the metabolism of oxygen in the eye, oxygen distribution was mapped in… Expand