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OPC 8490

Known as: OPC-8490, Piperazine, 1-(4-oxo-4-phenylbutyl)-4-((1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)carbonyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PiperazinesQuinolones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Subcellular mechanism of the positive inotropic effect of a new quinolinone derivative OPC-8490 on the dog ventricular myocardium
SummaryOPC-8490 [3,4-dihydro-6-[4-(4-oxo-4-phenylbutyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone citrate] elicited a positive… 
1996
1996
Mechanism of action of OPC-8490 in human ventricular myocardium.
BACKGROUND The quinolinone compounds OPC-8212 (vesnarinone), OPC-18790, and OPC-8490 are members of a family of unique positive… 
1993
1993
Effects of OPC-8490, a novel positive inotropic agent, on Ca[2+] and K[+] currents in single cardiac myocytes of the guinea-pig
1991
1991
[End-systolic pressure-volume relationships obtained by conductance catheter and transient inferior vena caval occlusion: their clinical usefulness].
Whether beneficial hemodynamic effects of cardiovascular drugs are due to changes in the inotropic or loading conditions has been… 
1990
1990
Effect of OPC-8490 on the membrane potentials and membrane currents of single guinea-pig myocytes
SummaryThe direct actions of OPC-8490 on mammalian myocardium were examined by determination of the drug's effects on the action… 
1990
1990
Voltage-dependent inhibition of the delayed outward potassium current by OPC-8490, a novel positive inotropic agent, in isolated atrial myocytes of guinea-pig heart
SummaryTo elucidate the ionic mechanisms underlying prolongation of the action potential by OPC-8490, a novel positive inotropic… 
Review
1989
Review
1989
New Inotropic Agents for Treatment of Heart Failure
New positive inotropic agents have been synthesized and they are under intensive research to examine whether they are different… 
1989
1989
-127-EFFECTS OF OPC-8490, A NEW INOTROPIC AGENT, ON HEMODYNAMICS, MYOCARDIAL FUNCTION AND METABOLISM IN EXPERIMENTAL ACUTE MYOCARDIAL ISCHEMIA : Cardiovascular Drugs : FREE COMMUNICATIONS(I…
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