OPA1 gene

Known as: NTG, mitochondrial dynamin-like GTPase, Dynamin-like 120 kDa protein, mitochondrial 
 
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
The mammalian mitochondrial inner membrane fusion protein OPA1 is controlled by complex patterns of alternative splicing and… (More)
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Highly Cited
2008
Highly Cited
2008
Dominant optic atrophy (DOA) is characterized by retinal ganglion cell degeneration leading to optic neuropathy. A subset of DOA… (More)
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Highly Cited
2008
Highly Cited
2008
Prohibitins comprise an evolutionarily conserved and ubiquitously expressed family of membrane proteins with poorly described… (More)
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Highly Cited
2007
Highly Cited
2007
Autosomal dominant optic atrophy (adOA) is a juvenile onset, progressive ocular disorder characterized by bilateral loss of… (More)
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Highly Cited
2007
Highly Cited
2007
OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria… (More)
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Highly Cited
2006
Highly Cited
2006
Many muscular and neurological disorders are associated with mitochondrial dysfunction and are often accompanied by changes in… (More)
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Highly Cited
2004
Highly Cited
2004
During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA interference, we manipulated the… (More)
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Highly Cited
2004
Highly Cited
2004
The regulated equilibrium between mitochondrial fusion and fission is essential to maintain integrity of the organelle… (More)
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Highly Cited
2001
Highly Cited
2001
We and others have shown recently that mutations in the OPA1 gene encoding a dynamin-related mitochondrial protein cause… (More)
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Highly Cited
2000
Highly Cited
2000
Autosomal dominant optic atrophy (ADOA) is the most prevalent hereditary optic neuropathy resulting in progressive loss of visual… (More)
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