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ONO-RS 082

Known as: ONO-RS-082 
 
National Institutes of Health

Papers overview

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2015
2015
Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice
Inflammatory mechanisms mediated by prostaglandins may contribute to the progression of intracerebral hemorrhage (ICH)-induced… Expand
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Highly Cited
2013
Highly Cited
2013
Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol.
Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and… Expand
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2009
2009
Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity.
BACKGROUND Prostaglandin (PG) E(2) exerts a variety of actions through 4 G protein-coupled receptors designated as EP(1), EP(2… Expand
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2005
2005
Prostacyclin attenuates oxidative damage of myocytes by opening mitochondrial ATP-sensitive K+ channels via the EP3 receptor.
Prostacyclin (PGI2) and the PGE family alleviate myocardial ischemia-reperfusion injury and limit oxidative damage. The… Expand
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Highly Cited
2004
Highly Cited
2004
Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development
Background and aims: Involvement of prostaglandin E2 (PGE2) receptors EP1, EP2, and EP4 in the formation of aberrant crypt foci… Expand
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Highly Cited
2002
Highly Cited
2002
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Accumulating evidence indicates that overproduction of prostanoids attributable to overexpression of cyclooxygenase-2 (COX-2… Expand
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Highly Cited
2002
Highly Cited
2002
Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts.
1. We examined the effects of endogenous prostaglandin E(2) (PGE(2)) on the production of interleukin-6 (IL-6), macrophage colony… Expand
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Highly Cited
2001
Highly Cited
2001
Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice.
Prostaglandin E2 (PGE2) is known to be the principal pro-inflammatory prostanoid and play an important role in nociception. To… Expand
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2001
2001
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.
Endogenous prostaglandins (PGs) play a central role in adaptive cytoprotection induced in the stomach by mild irritants. In the… Expand
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Highly Cited
1997
Highly Cited
1997
Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats.
BACKGROUND & AIMS Receptors activated by prostaglandin (PG) E2 are pharmacologically subdivided into four subtypes (EP1-EP4). The… Expand
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