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ONO-RS 082

Known as: ONO-RS-082 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity.
BACKGROUND Prostaglandin (PG) E(2) exerts a variety of actions through 4 G protein-coupled receptors designated as EP(1), EP(2… Expand
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2005
2005
Prostacyclin attenuates oxidative damage of myocytes by opening mitochondrial ATP-sensitive K+ channels via the EP3 receptor.
Prostacyclin (PGI2) and the PGE family alleviate myocardial ischemia-reperfusion injury and limit oxidative damage. The… Expand
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Highly Cited
2004
Highly Cited
2004
Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development
Background and aims: Involvement of prostaglandin E2 (PGE2) receptors EP1, EP2, and EP4 in the formation of aberrant crypt foci… Expand
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Highly Cited
2003
Highly Cited
2003
Facilitation by Endogenous Prostaglandins of Capsaicin-Induced Gastric Protection in Rodents through EP2 and IP Receptors
We investigated the role that prostaglandins (PGs) and EP receptors play in facilitating the gastroprotective action of capsaicin… Expand
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Highly Cited
2002
Highly Cited
2002
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Accumulating evidence indicates that overproduction of prostanoids attributable to overexpression of cyclooxygenase-2 (COX-2… Expand
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Highly Cited
2002
Highly Cited
2002
Regulation by PGE2 of the production of interleukin‐6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts
We examined the effects of endogenous prostaglandin E2 (PGE2) on the production of interleukin‐6 (IL‐6), macrophage colony… Expand
Highly Cited
2001
Highly Cited
2001
Characterization of EP receptor subtypes responsible for prostaglandin E2‐induced pain responses by use of EP1 and EP3 receptor knockout mice
Prostaglandin E2 (PGE2) is known to be the principal pro‐inflammatory prostanoid and play an important role in nociception. To… Expand
Highly Cited
2001
Highly Cited
2001
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.
Endogenous prostaglandins (PGs) play a central role in adaptive cytoprotection induced in the stomach by mild irritants. In the… Expand
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Highly Cited
2000
Highly Cited
2000
The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach
Aim: To investigate the EP receptor subtype involved in the gastroprotective action of prostaglandin (PG) E2 using various EP… Expand
Highly Cited
1997
Highly Cited
1997
Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats.
BACKGROUND & AIMS Receptors activated by prostaglandin (PG) E2 are pharmacologically subdivided into four subtypes (EP1-EP4). The… Expand
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