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Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition.
Diabetic retinopathy is a leading cause of adult vision loss and blindness. Much of the retinal damage that characterizes the disease results from retinal vascular leakage and nonperfusion. ThisExpand
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Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels.
Caveolae in endothelial cells have been implicated as plasma membrane microdomains that sense or transduce hemodynamic changes into biochemical signals that regulate vascular function. Therefore weExpand
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Lipopolysaccharide Induces Macrophage Migration via Prostaglandin D2 and Prostaglandin E2
Lipopolysaccharide (LPS) produces prostaglandins (PGs) concomitant to eliciting macrophage migration. We evaluated the role of PGs in initiating the migration of macrophages, especially focusing onExpand
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Decreased Endothelial Nitric-oxide Synthase (eNOS) Activity Resulting from Abnormal Interaction between eNOS and Its Regulatory Proteins in Hypoxia-induced Pulmonary Hypertension*
In the pulmonary artery isolated from 1-week hypoxia-induced pulmonary hypertensive rats, endothelial NO production stimulated by carbachol was decreased significantly in in situ visualization usingExpand
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Prostaglandin E2-prostanoid EP3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery.
Prostaglandin E2 (PGE2) is one major prostanoid produced under inflammatory situation. Although PGE2 is known to induce vascular contraction, its detailed mechanism remains unknown. In the presentExpand
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Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve.
The genetic loss of endothelial-derived nitric oxide synthase (eNOS) in mice impairs vascular endothelial growth factor (VEGF) and ischemia-initiated blood flow recovery resulting in critical limbExpand
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Anti‐inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice
We have recently reported that phytosteryl ferulates isolated from rice bran inhibit nuclear factor‐κB (NF‐κB) activity in macrophages. In the present study, we investigated the effect of γ‐oryzanolExpand
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Antioxidant, free radical-scavenging, and NF-kappaB-inhibitory activities of phytosteryl ferulates: structure-activity studies.
Some of the pharmacological properties of phytosteryl ferulates may be linked to their antioxidant potential. In this study, 2,2-diphenyl-1-picrylhydrazyl (DPPH), electron spin resonance (ESR), andExpand
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Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement
We investigated the role of prostaglandin D2 (PGD2) signaling in acute lung injury (ALI), focusing on its producer–effector interaction in vivo. Administration of endotoxin increased edema andExpand
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Classification and examination of halitosis.
In this paper, the classification of halitosis and the examination procedures used in diagnosing halitosis are outlined. Halitosis is classified into categories of genuine halitosis, pseudo-halitosisExpand
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