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ONO 6818

Known as: ONO-6818 
National Institutes of Health

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2 relations

Broader (2)

OxadiazolesPyrimidinones

Papers overview

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2005
2005
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
We developed a colitis model in Syrian hamsters (Mesocricetus auratus) to investigate the relationship between colitis and… 
2004
2004
Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We… 
2004
2004
1064-178 A novel oral neutrophil elastase inhibitor, ONO-6818, suppressed early atherosclerotic plaque formation in apolipoprotein E-knockout mice
2003
2003
ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation.
Highly Cited
2002
Highly Cited
2002
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
We investigated the effects of a novel oral neutrophil elastase inhibitor (ONO-6818) on acute lung injury and pulmonary emphysema… 
Review
2002
Review
2002
ONO-6818 Cortech/Ono.
ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech… 
2001
2001
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats
2001
2001
Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells.
Because interferon-gamma, interleukin-4, and interleukin-5 have been identified at the mRNA and protein levels in the lesional… 
2001
2001
Design and synthesis of new orally active inhibitors of human neutrophil elastase.
2001
2001
The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase.
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