ONO 6818

Known as: ONO-6818 
 
National Institutes of Health

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OxadiazolesPyrimidinones

Papers overview

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2005
2005
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
We developed a colitis model in Syrian hamsters (Mesocricetus auratus) to investigate the relationship between colitis and… (More)
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2004
2004
Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We… (More)
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2004
2004
1064-178 A novel oral neutrophil elastase inhibitor, ONO-6818, suppressed early atherosclerotic plaque formation in apolipoprotein E-knockout mice
 
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2003
2003
ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation.
BACKGROUND Among the serine proteases, neutrophil elastase is a powerful cytotoxic enzyme and plays a pivotal role in the… (More)
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Review
2002
Review
2002
ONO-6818 Cortech/Ono.
ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech… (More)
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2002
2002
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
We investigated the effects of a novel oral neutrophil elastase inhibitor (ONO-6818) on acute lung injury and pulmonary emphysema… (More)
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2001
2001
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats
 
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2001
2001
Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells.
Because interferon-gamma, interleukin-4, and interleukin-5 have been identified at the mRNA and protein levels in the lesional… (More)
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2001
2001
The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase.
The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1… (More)
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2001
2001
Design and synthesis of new orally active inhibitors of human neutrophil elastase.
To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n… (More)
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