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ONO 6818

Known as: ONO-6818 
 
National Institutes of Health

Papers overview

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2005
2005
We developed a colitis model in Syrian hamsters (Mesocricetus auratus) to investigate the relationship between colitis and… Expand
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2004
2004
Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We… Expand
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2003
2003
BACKGROUND Among the serine proteases, neutrophil elastase is a powerful cytotoxic enzyme and plays a pivotal role in the… Expand
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2002
2002
We investigated the effects of a novel oral neutrophil elastase inhibitor (ONO-6818) on acute lung injury and pulmonary emphysema… Expand
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Review
2002
Review
2002
  • A. Trifilieff
  • Current opinion in investigational drugs
  • 2002
  • Corpus ID: 31865961
ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech… Expand
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2001
2001
Because interferon-gamma, interleukin-4, and interleukin-5 have been identified at the mRNA and protein levels in the lesional… Expand
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2001
2001
The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1… Expand
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2001
2001
To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n… Expand
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