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ONO 6818

Known as: ONO-6818 
National Institutes of Health

Papers overview

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2005
2005
We developed a colitis model in Syrian hamsters (Mesocricetus auratus) to investigate the relationship between colitis and… 
2004
2004
Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We… 
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2003
2003
BACKGROUND Among the serine proteases, neutrophil elastase is a powerful cytotoxic enzyme and plays a pivotal role in the… 
Highly Cited
2002
Highly Cited
2002
We investigated the effects of a novel oral neutrophil elastase inhibitor (ONO-6818) on acute lung injury and pulmonary emphysema… 
Review
2002
Review
2002
ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech… 
2001
2001
Because interferon-gamma, interleukin-4, and interleukin-5 have been identified at the mRNA and protein levels in the lesional… 
2001
2001
The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1… 
2001
2001
To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n…