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ONO 4007

Known as: ONO-4007 
National Institutes of Health

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2 relations

Broader (1)

Lipid A
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
ONO-4007, a synthetic lipid A analog, induces Th1-type immune response in tumor eradication and restores nitric oxide production by peritoneal macrophages.
We have reported that ONO-4007, a novel synthetic lipid A derivative with low toxic activities, produced large amount of tumor… 
2002
2002
A lipid A analog ONO-4007 induces tolerance to plasma leakage in mice
Abstract.Objective: The effects of pretreatment with ONO-4007, a lipid A analog, on cutaneous plasma leakage induced by ONO-4007… 
2000
2000
Role of inflammatory mediators in lipid A analogue (ONO‐4007)‐induced vascular permeability change in mouse skin
Endotoxin shock is accompanied by an increase in peripheral vascular permeability. It has been postulated that most biological… 
1999
1999
Therapeutic effect of a new synthetic lipid A analog (ONO-4007) on a tumor implanted at different sites in rats.
The therapeutic effect of ONO-4007, a new lipid A analog, was examined on the 13762NF mammary adenocarcinoma in the F-344 rat… 
1998
1998
ONO‐4007 induces specific anti‐tumor immunity mediated by tumor necrosis factor-α
We investigated the therapeutic effects of ONO-4007, a novel synthetic lipid A derivative with low toxic activities, on… 
1998
1998
Intratumoral tumor necrosis factor induction and tumor growth suppression by ONO-4007, a low-toxicity lipid A analog.
BACKGROUND ONO-4007 is a lipid A analog with low toxicity. MATERIALS AND METHODS The antitumor activity and tumor necrosis… 
1998
1998
Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th2 to Th1 in tumor lesions.
BACKGROUND The antitumor effect exerted by tumor necrosis factor (TNF) is characteristic in that it causes central necrosis of… 
1997
1997
Therapeutic effects of a new synthetic lipid A analog, ONO-4007, on rat hepatoma KDH-8 depend on tumor necrosis factor-sensitivity of the tumor cells.
ONO-4007 is a new synthetic lipid A derivative with low endotoxic activities. ONO-4007 was effective against KDH-8, a tumor… 
1997
1997
Induction of tumor necrosis factor in a murine tumor by systemic administration of a novel synthetic lipid A analogue, ONO-4007.
The effect of a novel synthetic lipid A analogue, ONO-4007, on tumor necrosis factor (TNF) production was investigated in normal… 
1994
1994
ONO-4007, a new synthetic lipid A derivative, induces differentiation of rat myelomonocytic leukemia cells in vitro and in vivo.
We have examined the differentiation-inducing effects of ONO-4007, a new synthetic lipid A derivative with low endotoxic… 
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