Skip to search formSkip to main contentSkip to account menu

Null Allele

A mutation that results in either no gene product or the absence of function at the phenotypic level.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Simultaneous estimation of null alleles and inbreeding coefficients.
Although microsatellites are a very efficient tool for many population genetics applications, they may occasionally produce "null… 
Highly Cited
2007
Highly Cited
2007
The graded response to Sonic Hedgehog depends on cilia architecture.
Highly Cited
2003
Highly Cited
2003
Twist Regulates Cytokine Gene Expression through a Negative Feedback Loop that Represses NF-κB Activity
Highly Cited
2002
Highly Cited
2002
BAK1, an Arabidopsis LRR Receptor-like Protein Kinase, Interacts with BRI1 and Modulates Brassinosteroid Signaling
Highly Cited
1998
Highly Cited
1998
Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease
Highly Cited
1998
Highly Cited
1998
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
We describe a strategy for generating an allelic series of mutations at a given locus that requires the production of only one… 
Highly Cited
1998
Highly Cited
1998
Mutation in AP-3 δ in the mocha Mouse Links Endosomal Transport to Storage Deficiency in Platelets, Melanosomes, and Synaptic Vesicles
Highly Cited
1997
Highly Cited
1997
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in… 
Highly Cited
1994
Highly Cited
1994
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
The receptor tyrosine kinases (RTKs) expressed on the surface of endothelial cells are likely to play key roles in initiating the… 
Highly Cited
1993
Highly Cited
1993
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.
To directly assess c-myc function in cellular proliferation, differentiation, and embryogenesis, we have used homologous… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)