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Tracing European founder lineages in the Near Eastern mtDNA pool.
Founder analysis is a method for analysis of nonrecombining DNA sequence data, with the aim of identification and dating of migrations into new territory. The method picks out founder sequence typesExpand
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Using Environmental Correlations to Identify Loci Underlying Local Adaptation
Loci involved in local adaptation can potentially be identified by an unusual correlation between allele frequencies and important ecological variables or by extreme allele frequency differencesExpand
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Mutational processes of simple-sequence repeat loci in human populations.
Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly understood. We examined these processes by introducing a two-phase mutation model. In this model, most mutationsExpand
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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are notExpand
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Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes.
We present an expanded data set of 50 unlinked autosomal noncoding regions, resequenced in samples of Hausa from Cameroon, Italians, and Chinese. We use these data to make inferences about humanExpand
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Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels.
To characterize linkage disequilibrium (LD) levels in human populations, we have analyzed 10 independent noncoding segments in three population samples from the major ethnic groups--that is,Expand
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Adjusting the focus on human variation.
Studies of nuclear sequence variation are accumulating, such that we can expect a good description of the structure of human variation across populations and genomic regions in the near future. ThisExpand
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mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration?
To assess the extent to which the Nile River Valley has been a corridor for human migrations between Egypt and sub-Saharan Africa, we analyzed mtDNA variation in 224 individuals from variousExpand
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Branching pattern in the evolutionary tree for human mitochondrial DNA.
Eighty-eight types of mitochondrial (mt) DNA were found by sequencing the most variable part of the control region from 117 Caucasians. In the tree relating those types, most of the branching eventsExpand
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CYP3A variation and the evolution of salt-sensitivity variants.
Members of the cytochrome P450 3A subfamily catalyze the metabolism of endogenous substrates, environmental carcinogens, and clinically important exogenous compounds, such as prescription drugs andExpand
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