Nuclear Receptor Coactivators

Known as: Nuclear Receptor Coactivators [Chemical/Ingredient] 
Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
05101519962018

Related topics

Related topics

14 relations
In BloodProcess of secretionagonistsantagonists & inhibitors
(More)

Narrower (6)

NCOA4 protein, humanNCOA6 protein, humanNcoa6 protein, ratPpargc1b protein, rat
(More)

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Nuclear Receptor Coactivators
standards characteristics
physiological aspects
chemical synthesis
NCOA6 protein, human
agonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors.
Methylation of Lys-9 of histone H3 has been associated with repression of transcription. G9a is a histone H3 Lys-9… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.
Nuclear hormone receptors are ligand-dependent transcriptional regulators that modulate chromatin structure. However, the precise… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
Nuclear hormone receptors are ligand-activated transcription factors that regulate the expression of genes that are essential for… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 1
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.
The 2.7 A X-ray crystal structure of the HNF4gamma ligand binding domain (LBD) revealed the presence of a fatty acid within the… (More)
Is this relevant?
2002
2002
Nuclear receptor coactivators modulate hormone-dependent gene expression in brain and female reproductive behavior in rats.
Gonadal steroid hormones act in the brain to elicit changes in gene expression that result in profound effects on behavior and… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 4
  • figure 3
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors.
Transcriptional activation by nuclear hormone receptors is mediated by the 160-kDa family of nuclear receptor coactivators. These… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Transcription factor-specific requirements for coactivators and their acetyltransferase functions.
Different classes of mammalian transcription factors-nuclear receptors, cyclic adenosine 3',5'-monophosphate-regulated enhancer… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity.
The AIB1 gene was isolated upon microdissection of the homogeneously staining regions observed in breast cancer cell lines. It… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators.
Identical N-terminal deletions in the wild-type rat androgen receptor (rAR) and a constitutively active rAR (ARDelta641-902… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
Nuclear receptors regulate gene expression by direct activation of target genes and inhibition of AP-1. Here we report that… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?