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Nuclear Localization Signals

Known as: NLS Peptide, Nuclear Localization Signal Peptide, Nuclear Localization Signals [Chemical/Ingredient] 
Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with… 
National Institutes of Health

Related topics

Related topics

25 relations
BRCA1 protein, humanDAXX protein, humanFABP4 protein, humanIFI16 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal
ABSTRACT 5-Azacytidine- and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor suppressor genes silenced by promoter… 
Highly Cited
2002
Highly Cited
2002
Acute glucose starvation activates the nuclear localization signal of a stress‐specific yeast transcription factor
In yeast, environmental conditions control the transcription factor Msn2, the nuclear accumulation and function of which serve as… 
Highly Cited
2001
Highly Cited
2001
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload*
Considering that the development of hepatic lesions related to iron overload diseases might be a result of abnormally expressed… 
Highly Cited
1999
Highly Cited
1999
The Arginine-Rich Domains Present in Human Immunodeficiency Virus Type 1 Tat and Rev Function as Direct Importin β-Dependent Nuclear Localization Signals
ABSTRACT Protein nuclear import is generally mediated by basic nuclear localization signals (NLSs) that serve as targets for the… 
Highly Cited
1999
Highly Cited
1999
Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin α
  • B. Kobe
  • Nature Structural Biology
  • 1999
  • Corpus ID: 20026752
Importin α is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs… 
Highly Cited
1999
Highly Cited
1999
A peptide nucleic acid–nuclear localization signal fusion that mediates nuclear transport of DNA
We have combined a peptide nucleic acid (PNA) with the SV40 core nuclear localization signal (NLS), to create a bifunctional PNA… 
Review
1993
Review
1993
Nuclear localization signals (NLS).
Available data strongly suggest that simple karyophilic clusters of arginines and lysines in nucleus-targeted proteins signal the… 
Review
1988
Review
1988
Functional organization of the nuclear envelope.
MECHANISMS OF NUCLEOCYTOPLASMIC TRANSPORT 343 The Pore Complex as a Molecular Seive 344 Localization Sequences in Nuclear… 
Highly Cited
1987
Highly Cited
1987
Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor.
We have detected nuclear localization signals within the 795 amino acid rat glucocorticoid receptor. Using a transient expression… 
Highly Cited
1986
Highly Cited
1986
Synthetic peptides as nuclear localization signals
The nuclear envelope defines a compartment boundary which is penetrated by pores that mediate a remarkable transport process… 
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