Novastan

Ik-Kyung Jang, MD, FACC, David F. M. Brown, MD, Robert P. Giugliano, MD, SM, H. Vernon Anderson, MD, FACC,* Douglas Losordo, MD… (More)

Unfractionated heparin has enjoyed the sole anticoagulant status for almost half a century. Besides an effective anticoagulant… (More)

A multicenter clinical trial of the thrombin inhibitor argatroban (Novastan; Texas Biotechnology, Houston, TX; Smith-Kline… (More)

Despite the use of potent anticoagulants such as r-hirudin and argatroban, the morbidity/mortality of heparin-induced… (More)

From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair… (More)

We describe a case of a 70-year-old male who underwent coronary artery bypass surgery which was complicated by multiple… (More)

Because of the unsatisfactory options available for safe and effective antithrombotic therapy, recent, intense research and… (More)

Heparin-induced thrombocytopenia (HIT) is a syndrome that has been identified with increased frequency. The mortality associated… (More)