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Notch

Known as: notching 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling
Mutations in Drosophila rumi result in a temperature-sensitive loss of Notch signaling. Rumi is a protein O-glucosyltransferase… 
Review
2011
Review
2011
p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies
The p53 tumor suppressor protein has a key role in the induction of apoptosis of chronic lymphocytic leukemia (CLL) cells… 
2011
2011
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes
Notch signaling controls multiple developmental processes, thus demanding versatile functions. We have previously shown that this… 
Highly Cited
2011
Highly Cited
2011
A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis
BackgroundBuilding the complex vertebrate nervous system involves the regulated production of neurons and glia while maintaining… 
Highly Cited
2010
Highly Cited
2010
Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer.
Basal-like breast cancers (BLBC) are highly aggressive, yet selective therapies targeting the specific oncoproteins driving these… 
Review
2010
Review
2010
Role of glycans and glycosyltransferases in the regulation of Notch signaling.
The evolutionarily conserved Notch signaling pathway plays broad and important roles during embryonic development and in adult… 
2010
2010
NOTCH mutations as prognostic markers in T-ALL
Risk stratification plays a fundamental role in the treatment of acute lymphoblastic leukemia (ALL). Thus, patients harboring… 
Highly Cited
2008
Highly Cited
2008
Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling
The Notch receptor is essential for neural stem cell (NSC) characteristics. Relatively high concentrations (micromolar) of… 
2002
2002
The Soluble Notch Ligand, Jagged-1, Inhibits Proliferation of CD34+ Macrophage Progenitors
The Notch/Notch ligand system controls diverse cellular processes. The proteolytic cleavage generates transmembrane and soluble… 
Highly Cited
1997
Highly Cited
1997
Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.
Within the human ERBB-2 gene promoter, a 100-base pair region 5' to the TATA box enhances basal transcription 200-fold. Two… 
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