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Norfloxacin

Known as: NFLX, Norfloxacino, 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid 
A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (10)

AM-0715BaccidalMK-0366N-propylnorfloxacin

Broader (1)

Anti-Bacterial Agents
Bacterial InfectionsDecreased Protein Synthesis [PE]Drug AllergyEscherichia coli Infections

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Molecular imprinting-based separation methods for selective analysis of fluoroquinolones in soils.
Highly Cited
2005
Highly Cited
2005
Study of the interaction between fluoroquinolones and bovine serum albumin.
Highly Cited
2001
Highly Cited
2001
Chemiluminescence determination of some fluoroquinolone derivatives in pharmaceutical formulations and biological fluids using [Ru(bipy)(3)(2+)]-Ce(IV) system.
Highly Cited
2000
Highly Cited
2000
Determination of quinolones in plasma samples by capillary electrophoresis using solid-phase extraction.
Highly Cited
2000
Highly Cited
2000
Determination of quinolones in animal tissues and eggs by high-performance liquid chromatography with photodiode-array detection.
Highly Cited
2000
Highly Cited
2000
The qualitative and quantitative determination of quinolones of first and second generation by capillary electrophoresis.
Highly Cited
1999
Highly Cited
1999
Effects of NorA Inhibitors on In Vitro Antibacterial Activities and Postantibiotic Effects of Levofloxacin, Ciprofloxacin, and Norfloxacin in Genetically Related Strains ofStaphylococcus aureus
ABSTRACT NorA is a membrane-associated multidrug efflux protein that can decrease susceptibility to fluoroquinolones in… 
Highly Cited
1998
Highly Cited
1998
Epidemiology of severe hospital-acquired infections in patients with liver cirrhosis: effect of long-term administration of norfloxacin.
We performed a 5-year retrospective study to evaluate the effect of long-term administration of norfloxacin on the epidemiology… 
Highly Cited
1989
Highly Cited
1989
The comparative in vitro activity of ofloxacin and selected ophthalmic antimicrobial agents against ocular bacterial isolates.
Highly Cited
1983
Highly Cited
1983
Norfloxacin disposition after sequentially increasing oral doses
Single doses of norfloxacin (200, 400, 800, 1,200, and 1,600 mg) or placebo were administered orally at weekly intervals to 14… 
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