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Dupilumab Efficacy and Safety in Moderate‐to‐Severe Uncontrolled Asthma
TLDR
Patients who received dupilumab had significantly lower rates of severe asthma exacerbation than those who received placebo, as well as better lung function and asthma control. Expand
Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.
TLDR
Among adults with symptomatic chronic sinusitis and nasal polyposis refractory to intranasal corticosteroids, the addition of subcutaneous dupilumab to mometasone furoate nasal spray compared with mometAsone alone reduced endoscopic nasal polyp burden after 16 weeks. Expand
Comparative Pharmacokinetics and Pharmacodynamics of Pravastatin and Lovastatin
TLDR
Results indicate that, although pravastatin and lovastatin have very similar chemical structures and effects on serum lipids, they differ sharply in pharmacokinetic properties. Expand
Efficacy and Safety of Dupilumab in Glucocorticoid‐Dependent Severe Asthma
TLDR
In patients with glucocorticoid‐dependent severe asthma, dupilumab treatment reduced oral glucoc Corticoid use while decreasing the rate of severe exacerbations and increasing the FEV1. Expand
Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans
TLDR
Results are consistent with increases in LDL receptors available to clear IDL and LDL from blood during PCSK9 inhibition, and suggest that increased LDL receptors may also play a role in the reduction of plasma Lp(a) levels. Expand
Determination of norfloxacin, a new nalidixic acid analog, in human serum and urine by high-performance liquid chromatography
TLDR
A statistical evaluation of the assay data showed acceptable accuracy and precision for 0.1 to 10.0 micrograms of norfloxacin per ml of serum and for 1.0 to 500 micro grams of MK-366per ml of urine. Expand
Delivery of High-Quality Biomarker Assays
TLDR
Because of the escalation in demand for biomarker measurements, the highly-parallel (multi-plexed) assay platforms that have fueled the rise of genomics will likely evolve into the analytical engines that drive the biomarker laboratories of tomorrow. Expand
Norfloxacin disposition after sequentially increasing oral doses
TLDR
Crystals of the drug were occasionally observed during microscopic examination of freshly voided urine collected after the 1,200- and 1,600-mg doses, and Crystalluria was not encountered at lower doses. Expand
Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis.
TLDR
In a phase 2 trial of patients with active EoE, dupilumab reduced dysphagia, histologic features of disease (including eosinophilic infiltration and a marker of type 2 inflammation), and abnormal endoscopic features, compared with placebo, and was generally well tolerated. Expand
Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.
TLDR
The results strengthen the requirement of an enamino ester for binding to the dihydropyridine receptor and indicate a nonspecific role for the N3-substituent. Expand
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