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Nitracrine

Known as: 1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, Nitracrine [Chemical/Ingredient] 
Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
National Institutes of Health

Related topics

Related topics

14 relations

Broader (2)

Antineoplastic AgentsNucleic Acid Synthesis Inhibitors

Narrower (5)

C 137C 264C 684C-283
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Comparison of the cytotoxicity of two nitroheterocyclic drugs (NHCD) towards transformed and non-transformed cells.
2002
2002
Modulation of G2 arrest enhances cell death induced by the antitumor 1-nitroacridine derivative, Nitracrine
Nitracrine (Ledakrin) is an antitumor drug which is activated by cellular enzymes and binds covalently to DNA. Previous studies… 
1999
1999
Crosslinking of cellular DNA by nitracrine and furocoumarin derivatives.
The anticancer drug, nitracrine, a 1-nitro-9-aminoalkyl derivative of acridine exhibits potent cytotoxic effects which are due to… 
1992
1992
Bis-bioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide.
1990
1990
Hypoxia-selective antitumor agents. 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogues with varying side chains: the…
The nitroacridine derivative nitracrine is a potent hypoxia-selective cytotoxin for mammalian cells in culture. In an attempt to… 
1990
1990
Antitumor activity of 1-nitro-9-aminoacridines including nitracrine against some ascitic experimental tumors.
The antitumor activity of a few 1-nitro-9-aminoacridine derivatives including nitracrine was evaluated against ascitic forms of… 
1987
1987
Hypoxia-selective radiosensitization of mammalian cells by nitracrine, an electron-affinic DNA intercalator.
The radiosensitizing ability of the 1-nitroacridine nitracrine (NC) is of interest since it is an example of a DNA intercalating… 
Highly Cited
1986
Highly Cited
1986
Comparison of in vitro activity of cytotoxic drugs towards human carcinoma and leukaemia cell lines.
1983
1983
The mode of action of cytotoxic and antitumor 1-nitroacridines. III. In vivo interstrand cross-linking of DNA of mammalian or bacterial cells by 1-nitroacridines.
1979
1979
In vitro binding of metabolically activated [14C]-ledakrin, or 1-nitro-9-14C-(3'-dimethylamino-N-propylamino) acridine, a new antitumor and DNA cross-linking agent, to macromolecules of subcellular…
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