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Nitracrine
Known as:
1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-
, Nitracrine [Chemical/Ingredient]
Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
National Institutes of Health
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Related topics
Related topics
14 relations
Broader (2)
Antineoplastic Agents
Nucleic Acid Synthesis Inhibitors
Narrower (5)
C 137
C 264
C 684
C-283
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In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1990
1990
Metabolism of heterocyclic compounds in mouse liver microsomes
I. A. Degterev
,
A. A. Buzukov
,
N. K. Tatarskaya
,
E. Leonova
,
N. Sukhova
Pharmaceutical Chemistry Journal
1990
Corpus ID: 40305922
The metabolic transformation of nitroheterocyclic compounds (NHCC) in liver microsomes and tumor (Ehrlich ascites carcinoma, EAC…
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1990
1990
Structure, toxtcity, and antitumor activity of nitro-heterocyclic compounds, their metabolic activation in liver and tumor microsomes
V. N. Verovskii
,
A. Degterev
,
N. Sukhova
,
A. A. Buzukov
,
E. Leonova
,
N. K. Tatarskaya
Pharmaceutical Chemistry Journal
1990
Corpus ID: 37705739
The antitumor activity of nitro compounds is frequently associated with products of the metabolic reduction of the nitro groups…
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1989
1989
Nitracrine - an experimental hypoxia selective cytotoxin
B. Sutton
1989
Corpus ID: 92938279
1988
1988
Properties of nitracrine-nucleic acids complexes in selected enzymatic systems
E. Ciesielska
,
M. Piestrzeniewicz
,
W. Gałasiński
,
M. Gniazdowski
1988
Corpus ID: 89746930
1986
1986
The Structure of a Reduction Product of the Cytotoxic Drug Nitracrine
R. A. Marietzcurrena
,
E. J. Valente
1986
Corpus ID: 99740703
Dihydro-2,2-dimethyl- 1-( 3- (dimethyl- amino)propyl)- 1H-pyrimidino(4,5,6-de)acridine di- hydrochloride, C21H28N)+.2C1 -, M r…
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1983
1983
1H and 13C NMR characteristics of the anticancerous derivative of acridine: Ledakrin C-283 (nitracrine).
T. Wieczorkiewicz
,
B. Lubas
,
Z. Siatecki
,
H. Kozłowski
Acta Biochimica Polonica
1983
Corpus ID: 12839513
For the anticancerous derivative of acridine--Ledakrin C-283 [1-nitro-9-(3-dimethylaminopropylamino)-acridine . 2HCl-H2O] 1H and…
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1982
1982
Studies on antitumor and myelotoxic effect of Ledakrin and its selected analogues.
H. Glazman-Kuśnierczyk
,
C. Radzikowski
,
W. Budzynski
,
M. Paprocka
Archivum Immunologiae et Therapiae Experimentalis
1982
Corpus ID: 40792827
Ledakrin (Nitracrine) and its three analogues (C-846, C-857, C-1006) selected in primary in vitro and in vivo screening systems…
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1981
1981
Complexes of nitracrine with DNA. Stoichiometry of binding.
L. Szmigiero
,
M. Gniazdowski
Arzneimittel-Forschung
1981
Corpus ID: 34090644
In the presence of sulfhydryl compounds, an anticancer drug 1-nitro-9-(3-N,N-dimethylaminopropylamino) acridine (nitracrine…
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1980
1980
Cytotoxicity and the effect of combined treatment with X-rays of an anticancer 1-nitro-9-aminoacridine derivative in L5178Y-R and L5178Y-S cells.
I. Szumiel
,
M. Walicka
Neoplasma (Bratislava)
1980
Corpus ID: 23293558
The response to nitracrine, 1-nitro-9-[3'(N,N-dimethyl)aminopropyl] aminoacridine, an anticancer agent, was examined in two…
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1980
1980
Effect of cyclophosphamide vinblastine and nitracrine on bioelectric properties of the frog skin epithelium in vitro.
E. Wieraszko
Archivum Immunologiae et Therapiae Experimentalis
1980
Corpus ID: 3003118
The influence of cyclophosphamide, vinblastine and nitracrine on the membrane sodium transport was studied using the frog skin…
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