Nigericin

Known as: Nigericin [Chemical/Ingredient] 
A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck… (More)

Topic mentions per year

Topic mentions per year

1951-2018
020406019512017

Papers overview

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Highly Cited
2013
Highly Cited
2013
The NLRP3 inflammasome is an important component of the innate immune system. However, its mechanism of activation remains… (More)
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Highly Cited
2009
Highly Cited
2009
Fungal infections represent a serious threat, particularly in immunocompromised patients. Interleukin-1beta (IL-1beta) is a key… (More)
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Highly Cited
2007
Highly Cited
2007
Pannexin-1 is a recently identified membrane protein that can act as a nonselective pore permeable to dyes such as ethidium when… (More)
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Highly Cited
2006
Highly Cited
2006
A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates… (More)
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Highly Cited
2003
Highly Cited
2003
AbstractThe potassium ionophore nigericin induces cell death and promotes the maturation and release of IL-1β in… (More)
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Highly Cited
2001
Highly Cited
2001
The P2X(7) receptor (P2X(7)R) is an ATP-gated ion channel expressed by monocytes and macrophages. To directly address the role of… (More)
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Highly Cited
1994
Highly Cited
1994
Lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophages produce large quantities of interleukin (IL)-1 beta but in the… (More)
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Highly Cited
1993
Highly Cited
1993
A new method for the cytofluorimetric analysis of mitochondrial membrane potential in intact cells has been developed by using… (More)
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1992
1992
Mouse peritoneal macrophages stimulated with LPS produce large amounts of pro-IL-1 beta. When these cells were pulse-labeled with… (More)
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Highly Cited
1989
Highly Cited
1989
Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues. Major… (More)
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