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Some precautions in using chelators to buffer metals in biological solutions.
Chelators and associated computer programs are commonly used to buffer metal ions in biological experiments. This communication discusses common misunderstandings and pitfalls in use of these buffers… Expand
The Genome of the Sea Urchin Strongylocentrotus purpuratus
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined… Expand
Ecological Developmental Biology: Integrating Epigenetics, Medicine, And Evolution
PART I: ENVIRONMENTAL SIGNALS AND NORMAL DEVELOPMENT The Environment as a Normal Agent in Producing Phenotypes How Agents in the Environment Effect Molecular Changes in Development Developmental… Expand
Efflux transporters: newly appreciated roles in protection against pollutants.
- D. Epel, T. Luckenbach, C. Stevenson, Laura A. MacManus-Spencer, A. Hamdoun, T. Smital
- Biology, Medicine
- Environmental science & technology
- 1 June 2008
Although your high-school biology teacher might not have told you, cells are like nightclubs. They have to make sure that the right individuals come in and that the bad individuals—those who might… Expand
Embryo stability and vulnerability in an always changing world
Contrary to the view that embryos and larvae are the most fragile stages of life, development is stable under real-world conditions. Early cleavage embryos are prepared for environmental vagaries by… Expand
Emerging contaminants--pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms.
- T. Smital, T. Luckenbach, R. Sauerborn, A. Hamdoun, R. L. Vega, D. Epel
- Biology, Medicine
- Mutation research
- 18 August 2004
The environmental presence of chemosensitizers or inhibitors of the multixenobiotic resistance (MXR) defense system in aquatic organisms could cause increase in intracellular accumulation and toxic… Expand
Nitromusk and Polycyclic Musk Compounds as Long-Term Inhibitors of Cellular Xenobiotic Defense Systems Mediated by Multidrug Transporters
Synthetic musk compounds, widely used as fragrances in consumer products, have been detected in human tissue and, surprisingly, in aquatic organisms such as fish and mollusks. Although their… Expand
Intracellular pH and activation of sea urchin eggs after fertilisation
The intracellular pH of the sea urchin embryo increases 0.3 pH units between 1 and 4 min after fertilisation. The increase in pH is required for initiating development. The increase results from an… Expand
Changes in internal pH associated with initiation of motility and acrosome reaction of sea urchin sperm.
The changes in the intracellular pH (pHi) of sea urchin sperm associated with motility initiation and acrosome reaction were investigated using uptake of two different probes; 9-aminoacridine and… Expand
Use of multidrug transporters as first lines of defense against toxins in aquatic organisms
- D. Epel
- 1 May 1998
Abstract Multidrug transporters are ATP-dependent transport proteins which efflux a variety of moderately hydrophobic compounds out of cells. This article reviews the biology and chemistry of one… Expand