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Nicotinate phosphoribosyltransferase

Known as: NAPRTase, Nicotinic acid mononucleotide glycohydrolase, Nicotinic acid mononucleotide pyrophosphorylase 
National Institutes of Health

Related topics

Related topics

3 relations
NAPRT gene

Narrower (1)

Nicotinate phosphoribosyltransferase 1

Broader (1)

pentosyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Pediatric high-grade gliomas are among the deadliest of childhood cancers due to limited knowledge of early driving events in… 
Highly Cited
2018
Highly Cited
2018
Selective Cytotoxicity of the NAMPT Inhibitor FK866 Toward Gastric Cancer Cells With Markers of the Epithelial-Mesenchymal Transition, Due to Loss of NAPRT.
BACKGROUND & AIMS Markers of the epithelial-to-mesenchymal transition (EMT) in gastric tumor tissues are associated with poor… 
Highly Cited
2017
Highly Cited
2017
Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair.
In the last decade, substantial efforts have been made to identify NAD+ biosynthesis inhibitors, specifically against… 
Highly Cited
2015
Highly Cited
2015
Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.
Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein with intra- and extra-cellular functions as an enzyme… 
Highly Cited
2011
Highly Cited
2011
Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas
Olesen UH, Hastrup N, Sehested M. Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid… 
Highly Cited
2009
Highly Cited
2009
The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors
ABSTRACT GMX1777 is a prodrug of the small molecule GMX1778, currently in phase I clinical trials for the treatment of cancer. We… 
Highly Cited
2007
Highly Cited
2007
Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells*
NAD plays critical roles in various biological processes through the function of SIRT1. Although classical studies in mammals… 
2005
2005
The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases.
2004
2004
The pyridine-nucleotide cycle in tobacco
In order to elucidate the NAD-recycling pathway the following enzyme activities have been characterized in different tobacco… 
1974
1974
Activation of the de novo pathway for pyridine nucleotide biosynthesis prior to ricinine biosynthesis in castor beans.
The ricinine content of etiolated seedlings of Ricinus communis increased nearly 12-fold over a 4-day period. In plants… 
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