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NAPRT gene

Known as: NAPRT, NAPRT1, PP3856 
National Institutes of Health

Related topics

Related topics

1 relation
Nicotinate phosphoribosyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
Precision oncology hinges on linking tumour genotype with molecularly targeted drugs1; however, targeting the frequently… Expand
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2018
2018
Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment
Cross-resistance to drugs remains an unsolved problem in cancer chemotherapy. This study elucidates a molecular mechanism of… Expand
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2016
2016
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs… Expand
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Review
2015
Review
2015
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer.
NAD is a metabolite that is an important cofactor and second messenger for a number of cellular processes such as genomic… Expand
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Highly Cited
2013
Highly Cited
2013
Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor… Expand
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2013
2013
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or… Expand
2013
2013
Predictive Biomarkers and Personalized Medicine Loss of NAPRT 1 Expression by Tumor-Speci fi c Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor… Expand
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2012
2012
Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.
Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate… Expand
1999
1999
Hypoxanthine-guanine phosphoribosyltransferase deficiency and erythrocyte synthesis of pyridine coenzymes.
Purine and pyridine metabolism were studied in ten Lesch-Nyhan patients, with virtually no hypoxanthine-guanine… Expand
1971
1971
Inhibition of nicotinate phosphoribosyltransferase in human platelet lysate by nicotinic acid analogs.
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