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NAPRT gene

Known as: NAPRT, NAPRT1, PP3856 
 
National Institutes of Health

Related topics

Related topics

1 relation
Nicotinate phosphoribosyltransferase

Papers overview

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2019
2019
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
Precision oncology hinges on linking tumour genotype with molecularly targeted drugs1; however, targeting the frequently… Expand
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2018
2018
Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment
Cross-resistance to drugs remains an unsolved problem in cancer chemotherapy. This study elucidates a molecular mechanism of… Expand
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2016
2016
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs… Expand
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Review
2015
Review
2015
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer.
NAD is a metabolite that is an important cofactor and second messenger for a number of cellular processes such as genomic… Expand
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2013
2013
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or… Expand
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2013
2013
Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor… Expand
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2013
2013
Predictive Biomarkers and Personalized Medicine Loss of NAPRT 1 Expression by Tumor-Speci fi c Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor… Expand
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2012
2012
Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.
Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate… Expand
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1999
1999
Hypoxanthine-guanine phosphoribosyltransferase deficiency and erythrocyte synthesis of pyridine coenzymes.
Purine and pyridine metabolism were studied in ten Lesch-Nyhan patients, with virtually no hypoxanthine-guanine… Expand
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1971
1971
Inhibition of nicotinate phosphoribosyltransferase in human platelet lysate by nicotinic acid analogs.
 
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