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NAPRT gene
Known as:
NAPRT
, NAPRT1
, PP3856
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National Institutes of Health
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Related topics
Related topics
1 relation
Nicotinate phosphoribosyltransferase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
S. Chowdhry
,
C. Zanca
,
+12 authors
P. Mischel
Nature
2019
Corpus ID: 129945750
Precision oncology hinges on linking tumour genotype with molecularly targeted drugs1; however, targeting the frequently…
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2018
2018
Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment
Yoko Ogino
,
Akira Sato
,
F. Uchiumi
,
S. Tanuma
OncoTarget
2018
Corpus ID: 4899574
Cross-resistance to drugs remains an unsolved problem in cancer chemotherapy. This study elucidates a molecular mechanism of…
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Review
2015
Review
2015
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer.
D. Sampath
,
T. Zabka
,
D. Misner
,
T. O'Brien
,
P. Dragovich
Pharmacology and Therapeutics
2015
Corpus ID: 207365400
2015
2015
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
Sara Duarte-Pereira
,
Isabel Pereira-Castro
,
+5 authors
Raquel M. Silva
OncoTarget
2015
Corpus ID: 7576650
Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs…
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Highly Cited
2013
Highly Cited
2013
Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
D. Shames
,
Kristi Elkins
,
+13 authors
L. Belmont
Clinical Cancer Research
2013
Corpus ID: 10644220
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor…
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2013
2013
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
T. O'Brien
,
J. Oeh
,
+15 authors
D. Sampath
Neoplasia
2013
Corpus ID: 24738491
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or…
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2013
2013
Predictive Biomarkers and Personalized Medicine Loss of NAPRT 1 Expression by Tumor-Speci fi c Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
D. Shames
,
Kristi Elkins
,
+7 authors
L. Belmont
2013
Corpus ID: 31242975
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor…
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2012
2012
Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.
L. Galassi
,
M. Di Stefano
,
+4 authors
G. Magni
Biochimie
2012
Corpus ID: 8113468
1999
1999
Hypoxanthine-guanine phosphoribosyltransferase deficiency and erythrocyte synthesis of pyridine coenzymes.
V. Micheli
,
S. Sestini
,
+6 authors
G. Pompucci
Life Science
1999
Corpus ID: 25148829
1971
1971
Inhibition of nicotinate phosphoribosyltransferase in human platelet lysate by nicotinic acid analogs.
Z. Gaut
,
H. M. Solomon
Biochemical Pharmacology
1971
Corpus ID: 13466928
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