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Nicotinamide adenine dinucleotide (NAD)

Known as: DPN, Nicotinamide-Adenine Dinucleotide, Dinucleotide, Dihydronicotinamide Adenine 
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (27)

1,4,5,6-tetrahydronicotinamide adenine dinucleotide1-benzyl-1,4-dihydronicotinamide2'-deoxynicotinamide adenine dinucleotide3,4-dimethylpyridine adenine dinucleotide
4-nitro-4'-aminodiphenyl sulfoneIn BloodNADHProcess of secretion

Broader (6)

Adenine NucleotidesCoenzymesNucleotideschemical cofactor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
SummaryBackground FK866 is a potent inhibitor or NAD synthesis. This first-in-human study was performed to determine the maximum… 
Highly Cited
2001
Highly Cited
2001
Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening*
The yeast transcriptional repressor Sir2p silences gene expression from the telomeric, rDNA, and silent mating-type loci and may… 
Highly Cited
1997
Highly Cited
1997
The two isoenzymes for yeast NAD+‐dependent glycerol 3‐phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation
The two homologous genes GPD1 and GPD2 encode the isoenzymes of NAD‐dependent glycerol 3‐phosphate dehydrogenase in the yeast… 
Highly Cited
1988
Highly Cited
1988
Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene.
Highly Cited
1986
Highly Cited
1986
Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.
To determine the biochemical basis of the oxidant-induced injury of cells, we have studied early changes after exposure of P388D1… 
Highly Cited
1983
Highly Cited
1983
Effect of anthracycline antibiotics on oxygen radical formation in rat heart.
This investigation examined the effect of the anthracycline antitumor agents on reactive oxygen metabolism in rat heart. Oxygen… 
Highly Cited
1978
Highly Cited
1978
Rat liver peroxisomes catalyze the beta oxidation of fatty acids.
Peroxisomes were purified by differential and equilibrium density centrifugation from the livers of rats treated with clofibrate… 
Highly Cited
1974
Highly Cited
1974
Release of Adenosine from Ischemic Brain: Effect on Cerebral Vascular Resistance and Incorporation into Cerebral Adenine Nucleotides
A threefold increase in tissue adenosine levels was produced by ischemia in the dog and the rat brain within 1 minute; adenosine… 
Highly Cited
1962
Highly Cited
1962
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
Review
1948
Review
1948
The extinction coefficients of the reduced band of pyridine nucleotides.
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