FAQ

Nicotinamide adenine dinucleotide (NAD)

Known as: DPN, Nicotinamide-Adenine Dinucleotide, Dinucleotide, Dihydronicotinamide Adenine 
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature… (More)

Topic mentions per year

Topic mentions per year

1937-2018
020040060080019372017

Related topics

Related topics

43 relations

Narrower (26)

1,4,5,6-tetrahydronicotinamide adenine dinucleotide1-benzyl-1,4-dihydronicotinamide2'-deoxynicotinamide adenine dinucleotide3,4-dimethylpyridine adenine dinucleotide
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4-nitro-4'-aminodiphenyl sulfoneIn BloodNADHProcess of secretion
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Broader (6)

Adenine NucleotidesCoenzymesNucleotideschemical cofactor
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Nicotinamide adenine dinucleotide (NAD)
Nucleotides
physiological aspects
Coenzymes
NADH
chemical cofactor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
The human NAD metabolome: Functions, metabolism and compartmentalization
The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both… (More)
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Highly Cited
2009
Highly Cited
2009
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.
The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the… (More)
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Highly Cited
2009
Highly Cited
2009
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.
Many metabolic and physiological processes display circadian oscillations. We have shown that the core circadian regulator, CLOCK… (More)
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Highly Cited
2006
Highly Cited
2006
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy.
Axonal degeneration occurs in many neurodegenerative diseases and after traumatic injury and is a self-destructive program… (More)
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Highly Cited
2004
Highly Cited
2004
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
Axonal degeneration is an active program of self-destruction that is observed in many physiological and pathological settings. In… (More)
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Highly Cited
2002
Highly Cited
2002
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase
The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its… (More)
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Highly Cited
2001
Highly Cited
2001
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.
Clock:BMAL1 and NPAS2:BMAL1 are heterodimeric transcription factors that control gene expression as a function of the light-dark… (More)
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Highly Cited
2000
Highly Cited
2000
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.
Yeast Sir2 is a heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and… (More)
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Highly Cited
2000
Highly Cited
2000
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may… (More)
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Highly Cited
1967
Highly Cited
1967
The redox state of nicotinamide adenine dinucleotide in the cytoplasm and mitochondria of rat liver.
1. The concentrations of the oxidized and reduced substrates of the lactate-, beta-hydroxybutyrate- and glutamate-dehydrogenase… (More)
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