Nicotinamide adenine dinucleotide (NAD)

Known as: DPN, Nicotinamide-Adenine Dinucleotide, Dinucleotide, Dihydronicotinamide Adenine 
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature… (More)

Topic mentions per year

Topic mentions per year

1937-2018
020040060080019372017

Papers overview

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Review
2015
Review
2015
The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both… (More)
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Highly Cited
2009
Highly Cited
2009
The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the… (More)
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Highly Cited
2009
Highly Cited
2009
Many metabolic and physiological processes display circadian oscillations. We have shown that the core circadian regulator, CLOCK… (More)
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Highly Cited
2006
Highly Cited
2006
Axonal degeneration occurs in many neurodegenerative diseases and after traumatic injury and is a self-destructive program… (More)
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Highly Cited
2004
Highly Cited
2004
Axonal degeneration is an active program of self-destruction that is observed in many physiological and pathological settings. In… (More)
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Highly Cited
2002
Highly Cited
2002
The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its… (More)
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Highly Cited
2001
Highly Cited
2001
Clock:BMAL1 and NPAS2:BMAL1 are heterodimeric transcription factors that control gene expression as a function of the light-dark… (More)
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Highly Cited
2000
Highly Cited
2000
Yeast Sir2 is a heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and… (More)
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Highly Cited
2000
Highly Cited
2000
Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may… (More)
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Highly Cited
1967
Highly Cited
1967
1. The concentrations of the oxidized and reduced substrates of the lactate-, beta-hydroxybutyrate- and glutamate-dehydrogenase… (More)
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